Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 7/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CCR3 | P51677 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5191068 | 0.91 | LMNA (0.44) | OPRK1OPRM1OPRD1LMNAL3MBTL1 | |
| SCHEMBL5278583 | 0.87 | LMNA (0.44) | LMNAL3MBTL1CCR3MAPK1EGFR | |
| SCHEMBL5193992 | 0.86 | SMN1; SMN2 (0.48) | OPRK1OPRM1TDP1LMNAMEN1 | |
| SCHEMBL5190760 | 0.85 | ALDH1A1 (0.49) | TDP1MAPK1MEN1KMT2A | |
| SCHEMBL5193163 | 0.83 | SMN1; SMN2 (0.44) | LMNAL3MBTL1CCR3MAPK1MEN1 | |
| SCHEMBL5207365 | 0.81 | LMNA (0.41) | LMNAL3MBTL1CCR3MAPK1MEN1 | |
| SCHEMBL5192044 | 0.81 | KDM4E (0.48) | LMNAL3MBTL1MAPK1MEN1KMT2A | |
| SCHEMBL5190692 | 0.80 | ALDH1A1 (0.48) | OPRK1OPRM1OPRD1LMNAL3MBTL1 | |
| SCHEMBL5190894 | 0.78 | LMNA (0.53) | LMNAL3MBTL1KMT2A | |
| SCHEMBL5190656 | 0.77 | KMT2A (0.53) | TDP1L3MBTL1MAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | disclosed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | disclosed |