Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5193308 | 0.86 | POLB (0.47) | ALDH1A1MAPTKDM4ELMNATSHR | |
| SCHEMBL5193468 | 0.82 | ALDH1A1 (0.52) | ALDH1A1MAPTKDM4ELMNAHSD17B10 | |
| SCHEMBL5193913 | 0.79 | NPC1 (0.44) | ALDH1A1MAPTLMNANPC1RAB9A | |
| SCHEMBL5194854 | 0.77 | NPC1 (0.44) | ALDH1A1LMNANPC1RAB9AGAA | |
| SCHEMBL5191071 | 0.77 | LMNA (0.47) | MAPTLMNAGAA | |
| SCHEMBL5214027 | 0.76 | NPC1 (0.53) | ALDH1A1LMNANPC1RAB9APOLB | |
| SCHEMBL5194022 | 0.76 | ALDH1A1 (0.46) | ALDH1A1MAPTKDM4EHSD17B10POLB | |
| SCHEMBL5190984 | 0.74 | ALDH1A1 (0.41) | ALDH1A1MAPTKDM4ELMNACYP2C19 | |
| SCHEMBL5191129 | 0.72 | CA1 (0.46) | ALDH1A1MAPTCYP2C19NPC1RAB9A | |
| SCHEMBL8472774 | 0.71 | EPHX1 (0.54) | CHRM1HTR2AMCHR1MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | disclosed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | disclosed |