Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 9/20 | 0.41 |
| ▸ | PDE6D | O43924 | 1/20 | 0.41 |
| ▸ | PDE6A | P16499 | 1/20 | 0.41 |
| ▸ | PDE6G | P18545 | 1/20 | 0.41 |
| ▸ | PDE6B | P35913 | 1/20 | 0.41 |
| ▸ | PDE6C | P51160 | 1/20 | 0.41 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.41 |
| ▸ | FPR3 | P25089 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5192873 | 0.92 | LMNA (0.47) | LMNAGAAMAPTPDE5AFPR3 | |
| SCHEMBL5278574 | 0.88 | LMNA (0.48) | LMNAGAAPDE5AFPR3FPR2 | |
| SCHEMBL5193999 | 0.87 | ALDH1A1 (0.46) | LMNAGAAMAPT | |
| SCHEMBL5190763 | 0.86 | RXFP1 (0.46) | LMNAGAAPDE5AMEN1KMT2A | |
| SCHEMBL5193168 | 0.85 | RAB9A (0.47) | LMNAGAAKMT2A | |
| SCHEMBL5207369 | 0.83 | GAA (0.42) | LMNAGAAPDE5AKMT2A | |
| SCHEMBL5193468 | 0.82 | ALDH1A1 (0.52) | LMNAMAPTMEN1KMT2A | |
| SCHEMBL5190702 | 0.81 | GAA (0.49) | LMNAGAAMEN1KMT2A | |
| SCHEMBL5190900 | 0.79 | POLB (0.49) | GAAMAPTPDE5AKMT2A | |
| SCHEMBL5195267 | 0.78 | ALDH1A1 (0.41) | LMNAGAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | claimed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | claimed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | claimed |