Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.36 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5193913 | 0.81 | NPC1 (0.44) | ALDH1A1MEN1KMT2ALMNAHPGD | |
| SCHEMBL5278574 | 0.75 | LMNA (0.48) | LMNACCR3 | |
| SCHEMBL5190765 | 0.74 | CHRM1 (0.47) | ALDH1A1KDM4ELMNACYP2C19MAPT | |
| SCHEMBL5191885 | 0.74 | LMNA (0.44) | ALDH1A1MEN1KMT2AKDM4ELMNA | |
| SCHEMBL5193468 | 0.73 | ALDH1A1 (0.52) | ALDH1A1MEN1KMT2AKDM4ELMNA | |
| SCHEMBL5194080 | 0.71 | ALDH1A1 (0.46) | ALDH1A1MEN1KMT2AKDM4ELMNA | |
| SCHEMBL5213606 | 0.71 | KMT2A (0.60) | ALDH1A1MEN1KMT2AKDM4ELMNA | |
| SCHEMBL5192795 | 0.70 | NOS2 (0.49) | — | |
| SCHEMBL5193560 | 0.69 | CCR2 (0.48) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL5190775 | 0.69 | MAPT (0.49) | ALDH1A1MEN1KMT2ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | claimed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | claimed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | claimed |