Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR55 | Q9Y2T6 | 4/20 | 0.46 |
| ▸ | CNR2 | P34972 | 3/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.33 |
| ▸ | RARA | P10276 | 1/20 | 0.33 |
| ▸ | RARB | P10826 | 1/20 | 0.33 |
| ▸ | RARG | P13631 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | LDHB | P07195 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | NQO1 | P15559 | 3/20 | 0.33 |
| ▸ | GPR18 | Q14330 | 1/20 | 0.32 |
| ▸ | VKORC1 | Q9BQB6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14169832 | 0.90 | GPR55 (0.46) | GPR55CNR2ADORA3RARARARB | |
| SCHEMBL5189359 | 0.75 | NQO1 (0.44) | ADORA3NQO1VKORC1 | |
| SCHEMBL14172298 | 0.69 | GPR55 (0.41) | GPR55CNR2ESR1ESR2NQO1 | |
| SCHEMBL5348298 | 0.69 | GPR55 (0.49) | GPR55CNR2 | |
| SCHEMBL14170148 | 0.69 | CLK2 (0.50) | ADORA3ESR1ESR2NQO1 | |
| SCHEMBL5344643 | 0.69 | GPR55 (0.40) | GPR55CNR2 | |
| SCHEMBL11694849 | 0.67 | GPR55 (0.47) | GPR55CNR2ESR1ESR2LDHA | |
| SCHEMBL5119806 | 0.66 | GPR55 (0.38) | GPR55CNR2GPR18 | |
| SCHEMBL5191995 | 0.65 | NQO1 (0.55) | ADORA3NQO1VKORC1 | |
| SCHEMBL14169803 | 0.64 | CYP2C9 (0.53) | ADORA3NQO1VKORC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080153872-A1 | Bis-(Coumarin) Compounds With Anti-Inflammatory Activity | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2008-06-26 | — | — | US | disclosed |
| US-20080153872-A1 | Bis-(Coumarin) Compounds With Anti-Inflammatory Activity | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2008-06-26 | — | — | US | disclosed |
| EP-1846428-A1 | ANTI-INFLAMMATORY CONJUGATES OF MACROLIDES AND COUMARINS | GlaxoSmithKline istrazivacki centar Zagreb d.o.o. (HR) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006092739-A1 | ANTI-INFLAMMATORY CONJUGATES OF MACROLIDES AND COUMARINS | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) | 2006-09-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080153872-A1 | Bis-(Coumarin) Compounds With Anti-Inflammatory Activity | NOD1, NOD2, CASP1 | GPR55 2338/4885CNR2 739/4885ADORA3 2675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.