Sugi Predict

Sugi Predict / Compounds / SCHEMBL5348298

SCHEMBL5348298

SCHEMBL5348298

Cc1ccc(C(C)C)c2c(O)cc(=O)oc12

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GPR55 Q9Y2T6 3/20 0.49
▸ CYP3A4 P08684 4/20 0.46
▸ CYP1A2 P05177 2/20 0.46
▸ CYP2C19 P33261 2/20 0.46
▸ MEN1 O00255 1/20 0.46
▸ POLB P06746 1/20 0.46
▸ KMT2A Q03164 1/20 0.46
▸ GAA P10253 2/20 0.43
▸ ALDH1A1 P00352 2/20 0.43
▸ MCL1 Q07820 2/20 0.43
▸ MAOB P27338 2/20 0.43
▸ LMNA P02545 2/20 0.43
▸ KDM4E B2RXH2 2/20 0.43
▸ MGAM O43451 1/20 0.43
▸ TP53 P04637 1/20 0.43
▸ MAPT P10636 1/20 0.43
▸ SI P14410 1/20 0.43
▸ ALOX15 P16050 1/20 0.43
▸ MAPK1 P28482 1/20 0.43
▸ MGAM2 Q2M2H8 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5341413 0.88 CYP3A4 (0.46) GPR55CYP3A4CYP1A2CYP2C19MEN1
SCHEMBL5341491 0.83 CYP3A4 (0.50) CYP3A4CYP1A2CYP2C19MEN1POLB
SCHEMBL22622533 0.76 TRPA1 (0.45) GPR55CYP3A4GAAALDH1A1LMNA
SCHEMBL5336436 0.71 CYP3A4 (0.45) CYP3A4CYP1A2CYP2C19MEN1POLB
SCHEMBL23008681 0.70 ALDH1A1 (0.52) GPR55GAAALDH1A1LMNATP53
SCHEMBL5344934 0.70 MET (0.51) CYP3A4CYP1A2CYP2C19MEN1POLB
SCHEMBL24006403 0.69 GPR55 (0.36) GPR55CYP3A4CYP1A2CYP2C19MEN1
SCHEMBL14169832 0.69 GPR55 (0.46) GPR55MAPK1HSD17B10TSHRCNR2
SCHEMBL5190796 0.69 GPR55 (0.46) GPR55CNR2
SCHEMBL22840392 0.69 MAOB (0.67) CYP3A4POLBGAAALDH1A1MCL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080153872-A1 Bis-(Coumarin) Compounds With Anti-Inflammatory Activity PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) 2008-06-26 — — US disclosed
US-20080153872-A1 Bis-(Coumarin) Compounds With Anti-Inflammatory Activity PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) 2008-06-26 — — US disclosed
US-7208518-B2 Substituted furochromene compounds of antiinflammatory action GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) 2007-04-24 — — US disclosed
CN-1839138-A Substituted furochromene compounds with anti-inflammatory action PLIVA ISTRAZIVACKI INST D O O (HR) 2006-09-27 — — CN disclosed
US-20060148890-A1 Substituted furochromene compounds of antiinflammatory action PLIVA-LSTRAZIVACKI INSTITUT D.O.O. (HR) 2006-07-06 — — US disclosed
EP-1648901-A1 SUBSTITUTED FUROCHROMENE COMPOUNDS OF ANTIINFLAMMATORY ACTION PLIVA-ISTRAZIVACKI INSTITUT d.o.o. (HR) 2006-04-26 — — EP disclosed
WO-2005010006-A1 SUBSTITUTED FUROCHROMENE COMPOUNDS OF ANTIINFLAMMATORY ACTION PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) 2005-02-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080153872-A1 Bis-(Coumarin) Compounds With Anti-Inflammatory Activity NOD1, NOD2, CASP1 GPR55 2338/4885CYP3A4 17/4885CYP1A2 152/4885
US-20060148890-A1 Substituted furochromene compounds of antiinflammatory action LTC4S, CYP11B2, CYP11B1 GPR55 620/4885CYP3A4 76/4885CYP1A2 50/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.