Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | CCR2 | P41597 | 9/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.52 |
| ▸ | CCR5 | P51681 | 1/20 | 0.47 |
| ▸ | PREP | P48147 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5210355 | 0.90 | CCR2 (0.50) | TP53MAPTLMNACCR2KCNH2 | |
| SCHEMBL5192584 | 0.85 | CCR3 (0.51) | LMNACCR2KCNH2CCR5SMN1; SMN2 | |
| SCHEMBL5193739 | 0.84 | PKM (0.56) | MAPTLMNAPOLBSMN1; SMN2MEN1 | |
| SCHEMBL5193560 | 0.81 | CCR2 (0.48) | MAPTLMNACCR2KCNH2MEN1 | |
| SCHEMBL5190802 | 0.81 | CCR2 (0.47) | TP53MAPTLMNACCR2KCNH2 | |
| SCHEMBL5190834 | 0.80 | CCR2 (0.58) | TP53MAPTLMNACCR2KCNH2 | |
| SCHEMBL5193432 | 0.80 | MAPT (0.50) | TP53MAPTSMN1; SMN2MEN1RAB9A | |
| SCHEMBL5191220 | 0.80 | FAAH (0.51) | TP53MAPTLMNAPOLBSMN1; SMN2 | |
| SCHEMBL5193950 | 0.79 | CCR2 (0.46) | CCR2KCNH2CCR5MEN1KMT2A | |
| SCHEMBL5194091 | 0.76 | FAAH (0.53) | SMN1; SMN2MEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | disclosed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | disclosed |