Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 6/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.50 |
| ▸ | CCR3 | P51677 | 1/20 | 0.47 |
| ▸ | CCR5 | P51681 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5193432 | 0.91 | MAPT (0.50) | CCR3MEN1KMT2APKMMAPT | |
| SCHEMBL5192584 | 0.91 | CCR3 (0.51) | CCR2KCNH2CCR3CCR5MEN1 | |
| SCHEMBL5191591 | 0.90 | TP53 (0.53) | CCR2KCNH2CCR5MEN1KMT2A | |
| SCHEMBL5190802 | 0.88 | CCR2 (0.47) | CCR2KCNH2CCR3CCR5MEN1 | |
| SCHEMBL5193739 | 0.88 | PKM (0.56) | CCR3MEN1KMT2AALDH1A1PKM | |
| SCHEMBL5194091 | 0.87 | FAAH (0.53) | CCR3MEN1KMT2AALDH1A1PKM | |
| SCHEMBL5193560 | 0.84 | CCR2 (0.48) | CCR2KCNH2MEN1KMT2AALDH1A1 | |
| SCHEMBL5193950 | 0.82 | CCR2 (0.46) | CCR2KCNH2CCR5MEN1KMT2A | |
| SCHEMBL5192491 | 0.79 | ALDH1A1 (0.45) | MEN1KMT2AALDH1A1PKMLMNA | |
| SCHEMBL5190834 | 0.78 | CCR2 (0.58) | CCR2KCNH2CCR5MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | claimed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | claimed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | claimed |