Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.33 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.33 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5190984 | 0.74 | ALDH1A1 (0.41) | LMNAALDH1A1KDM4EKMT2ACYP2C19 | |
| SCHEMBL5278574 | 0.72 | LMNA (0.48) | LMNAEPHX2 | |
| SCHEMBL5194080 | 0.72 | ALDH1A1 (0.46) | LMNAALDH1A1KDM4EKMT2ANPSR1 | |
| SCHEMBL5191853 | 0.68 | POLB (0.52) | LMNAALDH1A1KDM4ECYP2C19SMN1; SMN2 | |
| SCHEMBL10818831 | 0.67 | KMT2A (0.55) | LMNAKMT2ACYP2C19NPSR1MEN1 | |
| SCHEMBL5544760 | 0.67 | CA1 (0.60) | LMNAALDH1A1EPHX1KDM4EKMT2A | |
| SCHEMBL17560403 | 0.67 | HTT (0.44) | LMNAALDH1A1EPHX1KDM4EKMT2A | |
| SCHEMBL20034965 | 0.67 | LMNA (0.57) | LMNAALDH1A1KMT2ACYP2C19NPSR1 | |
| SCHEMBL23178175 | 0.66 | KDM4E (0.47) | LMNAALDH1A1EPHX1KDM4EKMT2A | |
| SCHEMBL16420399 | 0.64 | CYP2C19 (0.51) | LMNAALDH1A1EPHX1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | claimed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | claimed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | claimed |