Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5278574 | 0.80 | LMNA (0.48) | LMNAGAA | |
| SCHEMBL5193913 | 0.77 | NPC1 (0.44) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL5194076 | 0.74 | ALDH1A1 (0.44) | ALDH1A1MAPTKDM4ELMNATP53 | |
| SCHEMBL5191885 | 0.72 | LMNA (0.44) | ALDH1A1KDM4ELMNANPSR1MEN1 | |
| SCHEMBL5190984 | 0.71 | ALDH1A1 (0.41) | ALDH1A1MAPTKDM4ELMNAMEN1 | |
| SCHEMBL5193020 | 0.71 | NOS2 (0.49) | — | |
| SCHEMBL5466150 | 0.70 | PKM (0.56) | ALDH1A1MAPTKDM4ELMNANAMPT | |
| SCHEMBL13873690 | 0.70 | EPHX2 (0.67) | ALDH1A1MAPTKDM4ENAMPTTHRB | |
| SCHEMBL13873669 | 0.69 | CYP2C9 (0.68) | MAPTKDM4ELMNANAMPTTP53 | |
| SCHEMBL5193432 | 0.69 | MAPT (0.50) | MAPTNAMPTTP53GAATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | claimed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | claimed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | claimed |