Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5190651 | 0.84 | KMT2A (0.42) | KMT2AMEN1NPC1SMN1; SMN2 | |
| SCHEMBL5195066 | 0.82 | KMT2A (0.48) | KMT2AMEN1POLBSMN1; SMN2 | |
| SCHEMBL5192491 | 0.80 | ALDH1A1 (0.45) | KMT2AMEN1GAANPC1SMN1; SMN2 | |
| SCHEMBL5192873 | 0.79 | LMNA (0.47) | KDM4EKMT2AMEN1MAPTGAA | |
| SCHEMBL5193432 | 0.79 | MAPT (0.50) | KMT2AMEN1MAPTGAARAB9A | |
| SCHEMBL5190018 | 0.78 | PKM (0.49) | KMT2AMEN1POLBGAANPC1 | |
| SCHEMBL5193335 | 0.77 | SMN1; SMN2 (0.49) | KDM4EKMT2AMEN1MAPTPOLB | |
| SCHEMBL5194091 | 0.77 | FAAH (0.53) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5193739 | 0.76 | PKM (0.56) | KMT2AMEN1MAPTPOLBRAB9A | |
| SCHEMBL5194854 | 0.76 | NPC1 (0.44) | KMT2AMEN1POLBGAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | claimed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | claimed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | claimed |