Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.46 |
| ▸ | EPAS1 | Q99814 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5195325 | 0.91 | SIGMAR1 (0.59) | KMT2AMEN1SIGMAR1POLBRAB9A | |
| SCHEMBL5190894 | 0.82 | LMNA (0.53) | L3MBTL1KMT2AGAASIGMAR1POLB | |
| SCHEMBL10681973 | 0.77 | SIGMAR1 (0.55) | KMT2AMEN1GAASIGMAR1POLB | |
| SCHEMBL5192044 | 0.75 | KDM4E (0.48) | L3MBTL1KMT2AMEN1MAPK1SMN1; SMN2 | |
| SCHEMBL5192328 | 0.74 | TDP1 (0.52) | KMT2AMEN1SIGMAR1POLBRAB9A | |
| SCHEMBL5193335 | 0.71 | SMN1; SMN2 (0.49) | KMT2AMEN1MAPK1SMN1; SMN2GAA | |
| SCHEMBL5193832 | 0.70 | FABP6 (0.46) | HTTKMT2AMEN1MAPK1GAA | |
| SCHEMBL27166226 | 0.70 | SIGMAR1 (0.69) | KMT2AMEN1MAPK1SMN1; SMN2SIGMAR1 | |
| SCHEMBL8944547 | 0.70 | SIGMAR1 (0.56) | GAASIGMAR1POLBALDH1A1LMNA | |
| SCHEMBL29713943 | 0.70 | SIGMAR1 (0.56) | GAASIGMAR1POLBALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | disclosed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | disclosed |