Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29713943 | 1.00 | SIGMAR1 (0.56) | SIGMAR1LMNAALDH1A1POLBGAA | |
| SCHEMBL26024193 | 0.90 | SIGMAR1 (0.54) | SIGMAR1 | |
| SCHEMBL123695 | 0.88 | SIGMAR1 (0.61) | SIGMAR1LMNAALDH1A1POLBGAA | |
| SCHEMBL6963422 | 0.85 | OPRD1 (0.55) | SIGMAR1ALDH1A1POLB | |
| SCHEMBL1907279 | 0.85 | OPRD1 (0.55) | SIGMAR1ALDH1A1POLB | |
| SCHEMBL20752939 | 0.84 | ALDH1A1 (0.47) | SIGMAR1ALDH1A1 | |
| SCHEMBL2471861 | 0.84 | SIGMAR1 (0.50) | SIGMAR1LMNAALDH1A1 | |
| SCHEMBL26024178 | 0.83 | RORC (0.51) | SIGMAR1ALDH1A1POLBGAA | |
| SCHEMBL25154604 | 0.83 | SIGMAR1 (0.57) | SIGMAR1LMNAALDH1A1POLBGAA | |
| SCHEMBL4283405 | 0.83 | SIGMAR1 (0.57) | SIGMAR1LMNAALDH1A1POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638568-B1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR (FR) | 1996-10-09 | — | — | EP | disclosed |
| US-5500426-A | ADMINISTERED TO IMPROVE GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-03-19 | — | — | US | disclosed |
| US-5492912-A | IMPROVES GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-02-20 | — | — | US | disclosed |
| EP-0638568-A1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-02-15 | — | — | EP | disclosed |