Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5193908 | 0.77 | LMNA (0.42) | LMNAMEN1KMT2ANPSR1GAA | |
| SCHEMBL5194080 | 0.74 | ALDH1A1 (0.46) | ALDH1A1KDM4ETP53LMNAMEN1 | |
| SCHEMBL5193020 | 0.69 | NOS2 (0.49) | — | |
| SCHEMBL5466150 | 0.68 | PKM (0.56) | ALDH1A1KDM4ETP53LMNASMN1; SMN2 | |
| SCHEMBL5191879 | 0.67 | LMNA (0.52) | KDM4ELMNAMEN1KMT2ANPSR1 | |
| SCHEMBL13873341 | 0.67 | EPHX2 (0.56) | KDM4ESMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL13873690 | 0.66 | EPHX2 (0.67) | ALDH1A1KDM4ETSHRKMT2AMAPT | |
| SCHEMBL13873668 | 0.65 | CYP2C9 (0.58) | ALDH1A1KDM4ELMNASMN1; SMN2TSHR | |
| SCHEMBL13873669 | 0.65 | CYP2C9 (0.68) | KDM4ETP53LMNATSHRMAPT | |
| SCHEMBL13873532 | 0.65 | NAMPT (0.48) | LMNASMN1; SMN2BCHEACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | claimed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | claimed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | claimed |