Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | FABP4 | P15090 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | EIF4E | P06730 | 1/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1995800 | 0.83 | TDP1 (0.46) | TSHRLMNAALDH1A1RORCEPAS1 | |
| SCHEMBL9512780 | 0.82 | MAPT (0.43) | TSHRTAS2R14LMNAMAPTHTT | |
| SCHEMBL1497989 | 0.81 | TSHR (0.60) | TSHRMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL28634094 | 0.80 | ALDH1A1 (0.38) | TSHRLMNAMAPTHTTAKR1B1 | |
| SCHEMBL28075340 | 0.79 | EPAS1 (0.51) | TSHRTAS2R14LMNAMAPTHTT | |
| SCHEMBL30490414 | 0.79 | TSHR (0.58) | TSHRMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL28171346 | 0.79 | TSHR (0.58) | TSHRMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL27771692 | 0.79 | TSHR (0.58) | TSHRMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL2792217 | 0.79 | GPR35 (0.56) | TSHRMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL3133064 | 0.79 | EIF4E (0.47) | TAS2R14LMNAMAPTHTTAKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3419609-B1 | TREATMENT OF ALKAPTONURIA AND TYROSINEMIA TYPE 1 | UNIV DEGLI STUDI DI SIENA (IT) | 2023-04-26 | — | — | EP | disclosed |
| EP-3419609-A1 | TREATMENT OF ALKAPTONURIA AND TYROSINEMIA TYPE 1 | Università degli Studi di Siena (IT) | 2019-01-02 | — | — | EP | disclosed |
| WO-2017144583-A1 | TREATMENT OF ALKAPTONURIA AND TYROSINEMIA TYPE 1 | UNIVERSITÀ DEGLI STUDI DI SIENA (IT) | 2017-08-31 | — | — | WO | disclosed |
| CN-105712944-A | Preparation method of isoxazole compound and isoxazole compound intermediate | 浙江省诸暨合力化学对外贸易有限公司 | 2016-06-29 | — | — | CN | disclosed |
| CN-105646356-A | Preparation method of sulfophenyl pyrazolone and intermediate thereof | 浙江省诸暨合力化学对外贸易有限公司 | 2016-06-08 | — | — | CN | disclosed |
| CN-101098852-A | Glycogen phosphorylase inhibitor compounds and pharmaceutical compositions thereof | SMITHKLINE BEECHAM CORP (US) | 2008-01-02 | — | — | CN | disclosed |
| US-20070249670-A1 | Glycogen Phosphorylase Inhibitor Compounds and Pharmaceutical Compositions Thereof | SMITHKLINE BEECHAM CORPORATION (US) | 2007-10-25 | — | — | US | disclosed |
| EP-1812383-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | Smithkline Beecham Corporation (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006052722-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249670-A1 | Glycogen Phosphorylase Inhibitor Compounds and Pharmaceutical Compositions Thereof | PYGM, PYGL, GYS1 | TSHR 4627/4885TAS2R14 4868/4885LMNA 444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.