Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5094870 | 0.81 | SIGMAR1 (0.39) | L3MBTL1SIGMAR1KDM4ESMN1; SMN2CHRM4 | |
| SCHEMBL5097000 | 0.73 | L3MBTL1 (0.41) | L3MBTL1SIGMAR1KDM4ESMN1; SMN2CYP2C19 | |
| SCHEMBL5195500 | 0.71 | L3MBTL1 (0.41) | L3MBTL1SIGMAR1KDM4ESMN1; SMN2CHRM4 | |
| SCHEMBL5090812 | 0.70 | OPRD1 (0.50) | L3MBTL1KDM4ESMN1; SMN2CYP2C19POLB | |
| SCHEMBL5090965 | 0.68 | KDM4E (0.42) | L3MBTL1KDM4ESMN1; SMN2CHRM4CYP2C19 | |
| SCHEMBL5503886 | 0.66 | CHRM1 (0.41) | L3MBTL1KDM4ESMN1; SMN2CHRM4CYP2C19 | |
| SCHEMBL5094849 | 0.64 | L3MBTL1 (0.39) | L3MBTL1SIGMAR1KDM4ESMN1; SMN2CYP2C19 | |
| SCHEMBL14012602 | 0.63 | HSD17B1 (0.43) | KDM4ECYP2C19CYP2D6ALDH1A1HSD17B10 | |
| SCHEMBL7397998 | 0.62 | DRD2 (0.72) | — | |
| SCHEMBL7397996 | 0.62 | DRD2 (0.72) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836196-A1 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006069275-A1 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-29 | — | — | WO | disclosed |