Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 3/20 | 0.39 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.38 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ENO1 | P06733 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4096002 | 0.83 | GPR119 (0.50) | GPR119KDM4EPKM | |
| SCHEMBL17740621 | 0.78 | FKBP1A (0.43) | CHRM4 | |
| SCHEMBL5811710 | 0.76 | CHRM4 (0.38) | CHRM4TEAD1TEAD3GPR119AKR1C3 | |
| SCHEMBL5811849 | 0.76 | CHRM4 (0.41) | CHRM4TEAD1TEAD3GPR119 | |
| SCHEMBL4104916 | 0.75 | SLC6A1 (0.39) | POLBGAANPSR1 | |
| SCHEMBL458216 | 0.74 | GPR119 (0.38) | TEAD1TEAD3GPR119AKR1C3KDM4E | |
| SCHEMBL4523080 | 0.74 | SLC18A3 (0.38) | CHRM4TEAD1TEAD3 | |
| Hydrochloric Acid SCHEMBL7424095 | 0.73 | GNAO1 (0.38) | POLBGAANPSR1 | |
| SCHEMBL12016032 | 0.73 | GNAI3 (0.45) | POLBPKM | |
| SCHEMBL6265066 | 0.73 | THRA (0.43) | AKR1C3KDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828176-A1 | TETRAHYDROQUINOLINE ANALOGUES AS MUSCARINIC AGONISTS | Acadia Pharmaceuticals Inc. (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006068904-A1 | TETRAHYDROQUINOLINE ANALOGUES AS MUSCARINIC AGONISTS | ACADIA PHARMACEUTICALS INC. (US) | 2006-06-29 | — | — | WO | disclosed |