Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL5198470 | 1.00 | HCAR2 (0.42) | HCAR2KMT2AGAAMAPTRAB9A | |
| Acetic Acid SCHEMBL5196852 | 0.88 | GAA (0.40) | KMT2AGAAMAPTRAB9ASMN1; SMN2 | |
| Formic Acid SCHEMBL5197972 | 0.84 | ALDH1A1 (0.36) | KMT2AGAAMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL752673 | 0.84 | TSHR (0.41) | KMT2AGAAMAPTRAB9ASMN1; SMN2 | |
| Phthalic Acid SCHEMBL5198532 | 0.83 | KMT2A (0.47) | KMT2ARAB9AMEN1NPC1LMNA | |
| Water SCHEMBL5196978 | 0.82 | TSHR (0.39) | KMT2AGAAMAPTRAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL31150435 | 0.82 | TSHR (0.39) | KMT2AGAAMAPTRAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL154108 | 0.82 | TSHR (0.39) | KMT2AGAAMAPTRAB9ASMN1; SMN2 | |
| Sulfuric Acid SCHEMBL2110043 | 0.81 | GAA (0.36) | KMT2AGAAMAPTRAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3327763 | 0.80 | TSHR (0.38) | KMT2AGAAMAPTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7220879-B2 | Method for inhibiting polymerization of (meth)acrylic acid and its esters using an inhibitor and a process for making a compound useful as such an inhibitor | ROHM AND HAAS COMPANY (US) | 2007-05-22 | — | — | US | claimed |
| EP-1647543-B1 | A method for inhibiting polymerization of (Meth) acrylic acid and its esters using an inhibitor and a process for making a compound useful as such an inhibitor | ROHM & HAAS (US) | 2007-05-02 | — | — | EP | claimed |
| EP-1647543-A1 | A method for inhibiting polymerization of (Meth) acrylic acid and its esters using an inhibitor and a process for making a compound useful as such an inhibitor | Rohm and Haas Company (US) | 2006-04-19 | — | — | EP | claimed |
| US-20060074257-A1 | Method for inhibiting polymerization of (meth)acrylic acid and its esters using an inhibitor and a process for making a compound useful as such an inhibitor | BASS STEPHEN | 2006-04-06 | — | — | US | claimed |
| US-20070197785-A1 | METHOD FOR INHIBITING POLYMERIZATION OF (METH) ACRYLIC ACID AND ITS ESTERS USING AN INHIBITOR AND A PROCESS FOR MAKING A COMPOUND USEFUL AS SUCH AN INHIBITOR | BASS STEPHEN | 2007-08-23 | — | — | US | disclosed |
| US-7253279-B1 | Method for inhibiting polymerization of (METH) acrylic acid and its esters using an inhibitor and a process for making a compound useful as such an inhibitor | ROHM AND HAAS COMPANY (US) | 2007-08-07 | — | — | US | disclosed |
| US-7220879-B2 | Method for inhibiting polymerization of (meth)acrylic acid and its esters using an inhibitor and a process for making a compound useful as such an inhibitor | ROHM AND HAAS COMPANY (US) | 2007-05-22 | — | — | US | disclosed |
| EP-1647543-B1 | A method for inhibiting polymerization of (Meth) acrylic acid and its esters using an inhibitor and a process for making a compound useful as such an inhibitor | ROHM & HAAS (US) | 2007-05-02 | — | — | EP | disclosed |
| EP-1647543-A1 | A method for inhibiting polymerization of (Meth) acrylic acid and its esters using an inhibitor and a process for making a compound useful as such an inhibitor | Rohm and Haas Company (US) | 2006-04-19 | — | — | EP | disclosed |
| US-20060074257-A1 | Method for inhibiting polymerization of (meth)acrylic acid and its esters using an inhibitor and a process for making a compound useful as such an inhibitor | BASS STEPHEN | 2006-04-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197785-A1 | METHOD FOR INHIBITING POLYMERIZATION OF (METH) ACRYLIC ACID AND ITS ESTERS USING AN INHIBITOR AND A PROCESS FOR MAKING A COMPOUND USEFUL AS SUCH AN INHIBITOR | MMAB, AZI2, MEP1A | KMT2A 421/4885MEN1 2242/4885HCAR2 365/4885 |
| US-20060074257-A1 | Method for inhibiting polymerization of (meth)acrylic acid and its esters using an inhibitor and a process for making a compound useful as such an inhibitor | MMAB, AZI2, MEP1A | KMT2A 421/4885MEN1 2242/4885HCAR2 365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.