Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | DAO | P14920 | 2/20 | 0.44 |
| ▸ | TYMP | P19971 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6472996 | 0.81 | DAO (0.52) | ALDH1A1KDM4EDAOLMNAMEN1 | |
| SCHEMBL15285375 | 0.80 | CYP1A2 (0.49) | ALDH1A1KDM4EDAOTYMPMEN1 | |
| SCHEMBL1346299 | 0.79 | IDH1 (0.49) | ALDH1A1KDM4EDAOTYMPLMNA | |
| SCHEMBL2178053 | 0.77 | SMN1; SMN2 (0.47) | KDM4EDAOLMNASMN1; SMN2MAPT | |
| SCHEMBL5201871 | 0.75 | PDE4A (0.44) | ALDH1A1KDM4ETYMPHTTPOLB | |
| SCHEMBL27657488 | 0.74 | IDH1 (0.58) | KDM4ELMNAHTTMEN1KMT2A | |
| SCHEMBL5256531 | 0.73 | L3MBTL1 (0.49) | TYMPLMNAHTTSMN1; SMN2MAPT | |
| SCHEMBL29105108 | 0.73 | BCL2 (0.47) | DAOMEN1KMT2ABCL2BCL2L1 | |
| SCHEMBL875676 | 0.72 | BCL2 (0.54) | ALDH1A1KDM4ELMNAHTTMEN1 | |
| SCHEMBL12432451 | 0.70 | KDM4E (0.53) | ALDH1A1KDM4ETYMPLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070299065-A1 | Tetrahydropyran Derivatives as Antidiabetics | MERCK PATENT GMBH (DE) | 2007-12-27 | — | — | US | disclosed |
| EP-1817323-A1 | TETRAHYDROPYRANE DERIVATIVES FOR USE AS ANTIDIABETICS | MERCK PATENT GmbH (DE) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006058597-A1 | TETRAHYDROPYRANE DERIVATIVES FOR USE AS ANTIDIABETICS | MERCK PATENT GMBH (DE) | 2006-06-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299065-A1 | Tetrahydropyran Derivatives as Antidiabetics | GPR119, GLP1R, INSR | ALDH1A1 749/4885KDM4E 2058/4885DAO 3236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.