Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 3/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | PIKFYVE | Q9Y2I7 | 2/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.32 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21097974 | 0.90 | ALDH1A1 (0.36) | HRH3ESR1ESR2 | |
| SCHEMBL25100553 | 0.79 | FDFT1 (0.36) | FDFT1CYP11B1 | |
| SCHEMBL746530 | 0.78 | TNKS (0.37) | HRH3FDFT1 | |
| SCHEMBL1142223 | 0.75 | KMT2A (0.37) | FDFT1 | |
| SCHEMBL5198999 | 0.74 | NR1H2 (0.33) | NR1H2NR1H3 | |
| SCHEMBL23956200 | 0.74 | FDFT1 (0.33) | FDFT1 | |
| SCHEMBL5950461 | 0.73 | ESR1 (0.46) | HRH3ESR1ESR2NR1H2NR1H3 | |
| SCHEMBL1141452 | 0.73 | DGAT1 (0.32) | — | |
| SCHEMBL13010773 | 0.73 | TSHR (0.39) | — | |
| SCHEMBL1056429 | 0.73 | ALDH1A1 (0.44) | HRH3ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070275968-A1 | Substituted Biphenyl Derivative | SANKYO COMPANY, LIMITED (JP) | 2007-11-29 | — | — | US | disclosed |
| US-7273938-B2 | Preparation of novel substituted haloarene compounds | PFIZER INC. (US) | 2007-09-25 | — | — | US | disclosed |
| CN-1989105-A | Preparation of novel substituted haloarene compounds | PFIZER (US) | 2007-06-27 | — | — | CN | disclosed |
| EP-1798229-A1 | SUBSTITUTED BIPHENYL DERIVATIVE | Sankyo Company, Limited (JP) | 2007-06-20 | — | — | EP | disclosed |
| EP-1771419-A1 | PREPARATION OF NOVEL SUBSTITUTED HALOARENE COMPOUNDS | Pfizer Products Inc. (US) | 2007-04-11 | — | — | EP | disclosed |
| US-20060030714-A1 | Preparation of novel substituted haloarene compounds | PFIZER INC | 2006-02-09 | — | — | US | disclosed |
| WO-2006011030-A1 | PREPARATION OF NOVEL SUBSTITUTED HALOARENE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2006-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060030714-A1 | Preparation of novel substituted haloarene compounds | HTR1A, HTR1D, HTR3D | HRH3 85/4885ESR1 1493/4885ESR2 1456/4885 |
| US-20070275968-A1 | Substituted Biphenyl Derivative | COL2A1, COL1A1, FGFR3 | HRH3 101/4885ESR1 2328/4885ESR2 977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.