Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.71 |
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | ACHE | P22303 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | GALR3 | O60755 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1097495 | 0.84 | TSHR (1.00) | TSHRGPR35MEN1KMT2AHTT | |
| SCHEMBL635130 | 0.84 | TSHR (0.90) | TSHRGPR35MEN1KMT2AHTT | |
| SCHEMBL593064 | 0.84 | CYP19A1 (0.62) | TSHRGPR35MEN1KMT2AHTT | |
| SCHEMBL69389 | 0.84 | ALDH1A1 (0.60) | TSHRGPR35MEN1KMT2AHTT | |
| SCHEMBL9265700 | 0.84 | ALDH1A1 (0.60) | TSHRGPR35MEN1KMT2AHTT | |
| Water SCHEMBL28180935 | 0.81 | CYP19A1 (0.59) | TSHRGPR35MEN1KMT2AHTT | |
| SCHEMBL30387741 | 0.81 | CYP19A1 (0.59) | TSHRGPR35MEN1KMT2AHTT | |
| SCHEMBL29381787 | 0.81 | CYP19A1 (0.59) | TSHRGPR35MEN1KMT2AHTT | |
| Phenol SCHEMBL28300096 | 0.80 | TSHR (0.61) | TSHRGPR35MEN1KMT2AHTT | |
| SCHEMBL16951605 | 0.75 | TSHR (0.65) | TSHRGPR35MEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12637445-B2 | KIF18A inhibitors | AMGEN INC. (US) | 2026-05-26 | — | — | US | disclosed |
| EP-4007756-B1 | KIF18A INHIBITORS | AMGEN INC (US) | 2025-12-24 | — | — | EP | disclosed |
| CN-118146176-B | GPR133/ADGRD1 agonist, preparation method and application thereof | 山东大学 | 2024-11-15 | — | — | CN | disclosed |
| CN-118146176-A | GPR133/ADGRD1 agonist, preparation method and application thereof | 山东大学 | 2024-06-07 | — | — | CN | disclosed |
| US-20220281843-A1 | KIF18A INHIBITORS | AMGEN INC. (US) | 2022-09-08 | — | — | US | disclosed |
| US-20220227739-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR | PROTEOSTASIS THERAPEUTICS INC (US) | 2022-07-21 | — | — | US | disclosed |
| EP-4007756-A1 | KIF18A INHIBITORS | Amgen Inc. (US) | 2022-06-08 | — | — | EP | disclosed |
| CN-108430994-B | Compounds, compositions and methods for modulating CFTR | 蛋白质平衡治疗股份有限公司 | 2022-04-12 | — | — | CN | disclosed |
| CN-114269731-A | KIF18A inhibitors | 美国安进公司 | 2022-04-01 | — | — | CN | disclosed |
| US-11136313-B2 | Compounds, compositions, and methods for modulating CFTR | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2021-10-05 | — | — | US | disclosed |
| US-20010053784-A1 | Imminoribitol PNP inhibitors, preparation thereof and use thereof | BIOCRYST PHARMACEUTICALS, INC (US) | 2001-12-20 | — | — | US | disclosed |
| US-6057349-A | ALPHA.SUB.1A/1L AGONISTS USED IN THE TREATMENT OF VARIOUS DISEASE STATES SUCH AS URINARY INCONTINENCE, NASAL CONGESTION, PRIAPISM, DEPRESSION, ANXIETY, DEMENTIA, SENILITY, ALZHEIMER'S, DEFICIENCIES IN ATTENTIVENESS AND COGNITION, AND | F. HOFFMAN LA ROCHE AG (CH) | 2000-05-02 | — | — | US | disclosed |
| US-5952362-A | INHIBITOR OF GLYCOGEN PHOSPHORYLASE ENZYMETIC ACTIVITY AND GLUCOSE ACITIVITY | SYNTEX (U.S.A) INC. (US) | 1999-09-14 | — | — | US | disclosed |
| EP-0887346-A2 | Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives, their preparation and their use as alpha1A/1L adrenoceptor agonists | F. HOFFMANN-LA ROCHE AG (CH) | 1998-12-30 | — | — | EP | disclosed |
| CN-1203228-A | Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives | HOFFMANN LA ROCHE (CH) | 1998-12-30 | — | — | CN | disclosed |
| US-4814518-A | SOLVENT EXTRACTION, AMINE SALTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-03-21 | — | — | US | disclosed |
| US-4496774-A | PREFERENTIAL COMPLEXING WITH CALCIUM BROMIDE | KOPPERS COMPANY, INC. (US) | 1985-01-29 | — | — | US | disclosed |
| US-4479019-A | TREATING MIXTURE WITH CALCIUM BROMIDE | KOPPERS COMPANY, INC. (US) | 1984-10-23 | — | — | US | disclosed |
| US-4447654-A | COMPLEXING WITH METAL HALIDE SALTS | KOPPERS COMPANY, INC. (US) | 1984-05-08 | — | — | US | disclosed |
| EP-0000784-B1 | 4-HYDROXY-2-BENZIMIDAZOLINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICAMENTS | Roche Diagnostics GmbH (DE) | 1981-08-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11136313-B2 | Compounds, compositions, and methods for modulating CFTR | CFTR, SCNN1B, SCNN1G | TSHR 3900/4885GPR35 1920/4885MEN1 4387/4885 |
| US-20220281843-A1 | KIF18A INHIBITORS | KIF18A, KIF18B, KIF15 | TSHR 4094/4885GPR35 3933/4885MEN1 2190/4885 |
| US-12637445-B2 | KIF18A inhibitors | KIF18A, KIF18B, KIF2C | TSHR 1994/4885GPR35 3958/4885MEN1 3774/4885 |
| US-20220227739-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR | CFTR, SCNN1B, SCNN1G | TSHR 3900/4885GPR35 1920/4885MEN1 4387/4885 |
| US-20010053784-A1 | Imminoribitol PNP inhibitors, preparation thereof and use thereof | PNP, PNLIP, PNPO | TSHR 2576/4885GPR35 2405/4885MEN1 3341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.