SCHEMBL5203464

SCHEMBL5203464

CC(c1ccc(Cl)cc1)C(CNC(=O)C1CCOC(C)(C)C1)c1ccc(Cl)cc1

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.48
POLB P06746 2/20 0.43
ALOX15 P16050 1/20 0.41
SMN1; SMN2 Q16637 3/20 0.39
GAA P10253 1/20 0.39
HPGD P15428 1/20 0.39
GLA P06280 1/20 0.37
CCR1 P32246 1/20 0.37
TP53 P04637 1/20 0.36
P2RX7 Q99572 2/20 0.36
CNR1 P21554 1/20 0.35
CNR2 P34972 1/20 0.35
KCNH2 Q12809 3/20 0.35
SCN5A Q14524 1/20 0.35
CACNA1I Q9P0X4 1/20 0.35
MAPT P10636 1/20 0.34
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
RAB9A P51151 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4831190 0.79 CNR1 (0.47) ALDH1A1POLBSMN1; SMN2GAAHPGD
SCHEMBL14064683 0.79 CNR1 (0.47) ALDH1A1POLBSMN1; SMN2GAAHPGD
SCHEMBL5201159 0.76 PKM (0.48) ALDH1A1POLBSMN1; SMN2GAAHPGD
SCHEMBL5200358 0.76 SMN1; SMN2 (0.41) SMN1; SMN2GAAHPGDCCR1TP53
SCHEMBL5200515 0.75 MGLL (0.44) ALDH1A1SMN1; SMN2GAAHPGDTP53
SCHEMBL5206255 0.73 MEN1 (0.41) SMN1; SMN2GAAHPGDCCR1TP53
SCHEMBL5202582 0.73 MEN1 (0.38) ALDH1A1SMN1; SMN2HPGDTP53P2RX7
SCHEMBL5205796 0.72 HPGD (0.46) ALDH1A1SMN1; SMN2GAAHPGDCCR1
SCHEMBL4689271 0.71 RAB9A (0.48) ALDH1A1SMN1; SMN2GAAHPGDKCNH2
SCHEMBL5489953 0.71 TP53 (0.53) TP53MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1490043-A4 SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS MERCK & CO INC (US) 2007-05-30 EP claimed
EP-1490043-A2 SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS Merck & Co., Inc. (US) 2004-12-29 EP claimed
WO-2003082190-A2 SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS MERCK & CO., INC. (US) 2003-10-09 WO claimed
EP-1490043-A4 SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS MERCK & CO INC (US) 2007-05-30 EP disclosed
EP-1490043-A2 SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS Merck & Co., Inc. (US) 2004-12-29 EP disclosed
WO-2003082190-A2 SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS MERCK & CO., INC. (US) 2003-10-09 WO disclosed