Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.30 |
| ▸ | RAB9A | P51151 | 2/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5208877 | 0.95 | PIK3CA (0.35) | PIK3CAPIK3CBCYP3A4CYP2C9CYP2C19 | |
| Trifluoroacetic Acid SCHEMBL5208291 | 0.85 | MAPT (0.33) | MAPTLMNATPSAB1NPC1RAB9A | |
| SCHEMBL5210132 | 0.85 | F2 (0.39) | MAPTLMNAMEN1KMT2AALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL5206023 | 0.84 | ENPP2 (0.36) | — | |
| Trifluoroacetic Acid SCHEMBL5208518 | 0.84 | FLT3 (0.38) | MAPTLMNAMEN1KMT2ANPSR1 | |
| Trifluoroacetic Acid SCHEMBL5204591 | 0.82 | F10 (0.33) | PIK3CAPIK3CBMAPTGPBAR1KMT2A | |
| SCHEMBL6991435 | 0.82 | F2 (0.35) | MAPTLMNAMEN1KMT2AALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL5204634 | 0.81 | MAPK10 (0.36) | PIK3CAPIK3CBMAPTMEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL5209006 | 0.81 | PIK3CA (0.33) | PIK3CAPIK3CBGPBAR1MEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL5205966 | 0.79 | PDE4D (0.39) | MAPTLMNANPSR1ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343561-B1 | SERINE PROTEASE INHIBITORS | TULARIK LTD (GB) | 2007-02-28 | — | — | EP | disclosed |
| EP-1343561-A1 | SERINE PROTEASE INHIBITORS | Tularik Limited (GB) | 2003-09-17 | — | — | EP | disclosed |
| WO-2002047762-A1 | SERINE PROTEASE INHIBITORS | TULARIK LIMITED (GB) | 2002-06-20 | — | — | WO | disclosed |