Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.50 |
| ▸ | TNIK | Q9UKE5 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | CASP1 | P29466 | 3/20 | 0.47 |
| ▸ | CASP7 | P55210 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.44 |
| ▸ | CBFB | Q13951 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202344 | 0.90 | SCN9A (0.47) | MAPTTNIKKMT2AMEN1TSHR | |
| SCHEMBL6473796 | 0.90 | MAPT (0.51) | MAPTTNIKKMT2AMEN1TSHR | |
| SCHEMBL6480001 | 0.86 | MAPT (0.49) | MAPTTNIKKMT2AMEN1TSHR | |
| SCHEMBL6480285 | 0.82 | AURKA (0.53) | MAPTKMT2AMEN1TSHRLMNA | |
| SCHEMBL6474559 | 0.81 | GAA (0.43) | MAPTTNIKKMT2AMEN1LMNA | |
| SCHEMBL5204470 | 0.79 | MEN1 (0.42) | MAPTTNIKKMT2AMEN1TSHR | |
| SCHEMBL6481407 | 0.75 | AURKA (0.47) | MAPTKMT2AMEN1TSHRLMNA | |
| SCHEMBL6474359 | 0.75 | MEN1 (0.43) | MAPTKMT2AMEN1TSHRLMNA | |
| SCHEMBL11555581 | 0.71 | GAA (0.61) | MAPTTNIKKMT2AMEN1LMNA | |
| SCHEMBL6472908 | 0.71 | TTBK1 (0.43) | MAPTKMT2AMEN1TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6916820-B1 | Neurotrophic substituted pyrimidines | KRENITSKY PHARMACEUTICALS, INC. (US) | 2005-07-12 | — | — | US | claimed |