Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 7/20 | 0.47 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.44 |
| ▸ | RBP4 | P02753 | 4/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 2/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5204533 | 0.86 | ALDH1A1 (0.46) | PROKR1TPSAB1RBP4ALDH1A1SMN1; SMN2 | |
| SCHEMBL5203757 | 0.86 | NPC1 (0.57) | TPSAB1ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL4862667 | 0.83 | TSHR (0.47) | PROKR1TPSAB1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL5206419 | 0.80 | SMN1; SMN2 (0.49) | PROKR1TPSAB1RBP4ALDH1A1SMN1; SMN2 | |
| SCHEMBL4853409 | 0.80 | SLC2A1 (0.50) | ALDH1A1NPC1RAB9AATMKMT2A | |
| SCHEMBL4860093 | 0.79 | ALDH1A1 (0.45) | PROKR1TPSAB1RBP4ALDH1A1SMN1; SMN2 | |
| SCHEMBL5204500 | 0.78 | TPSAB1 (0.47) | PROKR1TPSAB1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL5203268 | 0.77 | GAA (0.48) | ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL5202510 | 0.77 | HSD11B1 (0.55) | PROKR1TPSAB1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL4853030 | 0.76 | HDAC3 (0.46) | RBP4ALDH1A1SMN1; SMN2HRH2SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |