Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 2/20 | 0.48 |
| ▸ | ANPEP | P15144 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | KLK7 | P49862 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5192328 | 0.83 | TDP1 (0.52) | POLBALDH1A1KDM4ETDP1KLK7 | |
| SCHEMBL5206469 | 0.80 | POLB (0.50) | POLBALDH1A1CSF1RKDM4ETDP1 | |
| SCHEMBL5193832 | 0.80 | FABP6 (0.46) | POLBMAPK1ALDH1A1KDM4ETDP1 | |
| SCHEMBL5191198 | 0.76 | MAPK1 (0.56) | POLBMAPK1ALDH1A1KDM4ETDP1 | |
| SCHEMBL5206456 | 0.75 | MAPK1 (0.58) | POLBMAPK1ALDH1A1CSF1RKDM4E | |
| SCHEMBL5192506 | 0.74 | ALDH1A1 (0.47) | MAPK1ALDH1A1KDM4E | |
| SCHEMBL7167924 | 0.70 | MAPK1 (0.69) | POLBMAPK1ALDH1A1KDM4EMMP2 | |
| SCHEMBL5190894 | 0.70 | LMNA (0.53) | POLBALDH1A1KDM4E | |
| SCHEMBL5190175 | 0.69 | ALDH1A1 (0.45) | ALDH1A1KDM4EABCB1 | |
| SCHEMBL5192047 | 0.68 | KMT2A (0.45) | MAPK1ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | disclosed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | disclosed |