Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 4/20 | 0.46 |
| ▸ | LCK | P06239 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 4/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
| ▸ | KDM6B | O15054 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7899162 | 0.86 | CA2 (0.48) | FOLH1LCKKDM4EEGFRALOX15 | |
| SCHEMBL7433937 | 0.85 | KDM6B (0.57) | FOLH1LCKKDM4EUSP2EGFR | |
| SCHEMBL22364281 | 0.85 | KDM6B (0.57) | FOLH1LCKKDM4EUSP2EGFR | |
| SCHEMBL29700186 | 0.85 | KDM6B (0.57) | FOLH1LCKKDM4EUSP2EGFR | |
| SCHEMBL23917908 | 0.78 | KMT2A (0.47) | FOLH1HSD17B10TDP1MMEACE | |
| SCHEMBL2558965 | 0.78 | SLC7A5 (0.71) | LCKKDM4EUSP2EGFRFYN | |
| SCHEMBL2556864 | 0.78 | KDM6B (0.68) | LCKKDM4EUSP2EGFRFYN | |
| SCHEMBL2554990 | 0.78 | SLC7A5 (0.71) | LCKKDM4EUSP2EGFRFYN | |
| SCHEMBL14032222 | 0.78 | ALOX15 (0.49) | LCKKDM4EUSP2EGFRFYN | |
| SCHEMBL2558959 | 0.78 | SLC7A5 (0.71) | LCKKDM4EUSP2EGFRFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1124824-B1 | CHROMENONE AND CHROMANONE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GMBH (DE) | 2007-08-22 | — | — | EP | disclosed |
| EP-1124824-A1 | CHROMENONE AND CHROMANONE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GmbH (DE) | 2001-08-22 | — | — | EP | disclosed |
| WO-2000026212-A1 | CHROMENONE AND CHROMANONE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GMBH (DE) | 2000-05-11 | — | — | WO | disclosed |