Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 4/20 | 0.51 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5207887 | 0.90 | KDM4E (0.60) | KDM4EMTNR1AMTNR1BMEN1TP53 | |
| SCHEMBL5213599 | 0.85 | ICMT (0.61) | ICMTKDM4EMEN1USP2LMNA | |
| SCHEMBL5208637 | 0.84 | ICMT (0.49) | ICMTMEN1TP53KMT2ACDK2 | |
| SCHEMBL5206707 | 0.84 | ICMT (0.53) | ICMTMTNR1AMTNR1BLMNACNR2 | |
| SCHEMBL5211211 | 0.81 | HTR1D (0.48) | ICMTLMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5213952 | 0.81 | ICMT (0.47) | ICMTKDM4EMEN1USP2LMNA | |
| SCHEMBL5210851 | 0.81 | MAPT (0.60) | MEN1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5209045 | 0.80 | CDK2 (0.49) | ICMTMTNR1AMTNR1BMEN1KMT2A | |
| SCHEMBL5210504 | 0.80 | TSHR (0.56) | ICMTKDM4EMTNR1AMTNR1B | |
| SCHEMBL22470068 | 0.79 | KDM4E (0.74) | ICMTKDM4EMTNR1AMTNR1BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7288564-B2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 2007-10-30 | — | — | US | claimed |
| EP-1343757-B1 | INDOLE DERIVATIVES | GLAXO GROUP LTD (GB) | 2007-02-14 | — | — | EP | disclosed |