Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 6/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.44 |
| ▸ | ACLY | P53396 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 2/20 | 0.40 |
| ▸ | F10 | P00742 | 2/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5210504 | 0.92 | TSHR (0.56) | ICMTTSHRANO1MAPTNPSR1 | |
| SCHEMBL5213952 | 0.85 | ICMT (0.47) | ICMTCNR2MAPTNPSR1ALDH1A1 | |
| SCHEMBL5207800 | 0.84 | ICMT (0.51) | ICMTCNR2MTNR1AMTNR1BLMNA | |
| SCHEMBL5209045 | 0.84 | CDK2 (0.49) | ICMTMAPTNPSR1MTNR1AMTNR1B | |
| SCHEMBL5213599 | 0.83 | ICMT (0.61) | ICMTCNR2MAPTNPSR1ALDH1A1 | |
| SCHEMBL5211211 | 0.83 | HTR1D (0.48) | ICMTCNR2MAPTNPSR1ALDH1A1 | |
| SCHEMBL5208637 | 0.83 | ICMT (0.49) | ICMTCNR2ACLYMAPTALDH1A1 | |
| SCHEMBL5210851 | 0.82 | MAPT (0.60) | TSHRMAPTNPSR1ALDH1A1LMNA | |
| SCHEMBL5207887 | 0.82 | KDM4E (0.60) | MAPTMPOMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL5214070 | 0.77 | PPARG (0.57) | MAPTALDH1A1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7288564-B2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 2007-10-30 | — | — | US | claimed |
| EP-1343757-B1 | INDOLE DERIVATIVES | GLAXO GROUP LTD (GB) | 2007-02-14 | — | — | EP | disclosed |