Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5206707 | 0.85 | ICMT (0.53) | ICMTLMNAALDH1A1SMN1; SMN2CNR2 | |
| SCHEMBL5207800 | 0.81 | ICMT (0.51) | ICMTTP53LMNAKDM4ECNR2 | |
| SCHEMBL5209045 | 0.81 | CDK2 (0.49) | ICMTSMN1; SMN2MEN1KMT2ANPSR1 | |
| SCHEMBL5210504 | 0.81 | TSHR (0.56) | ICMTKDM4ESMN1; SMN2NPSR1MAPT | |
| SCHEMBL5211211 | 0.80 | HTR1D (0.48) | ICMTLMNAALDH1A1SMN1; SMN2CNR2 | |
| SCHEMBL5208637 | 0.80 | ICMT (0.49) | ICMTTP53ALDH1A1SMN1; SMN2CNR2 | |
| SCHEMBL5210851 | 0.79 | MAPT (0.60) | HTTLMNAALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL5207887 | 0.79 | KDM4E (0.60) | TP53KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL5213599 | 0.79 | ICMT (0.61) | ICMTLMNAKDM4EALDH1A1CNR2 | |
| SCHEMBL23701730 | 0.78 | TSHR (0.57) | ICMTHTTLMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343757-B1 | INDOLE DERIVATIVES | GLAXO GROUP LTD (GB) | 2007-02-14 | — | — | EP | disclosed |