Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 3/20 | 0.49 |
| ▸ | CDK2 | P24941 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | PYGL | P06737 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5207800 | 0.84 | ICMT (0.51) | ICMTCDK2CNR2MEN1KMT2A | |
| SCHEMBL5206707 | 0.83 | ICMT (0.53) | ICMTMAPTSMN1; SMN2CNR2ALDH1A1 | |
| SCHEMBL5211211 | 0.80 | HTR1D (0.48) | ICMTMAPTSMN1; SMN2CNR2ALDH1A1 | |
| SCHEMBL5213952 | 0.80 | ICMT (0.47) | ICMTMAPTSMN1; SMN2CNR2MEN1 | |
| SCHEMBL5210851 | 0.79 | MAPT (0.60) | CDK2MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL5209045 | 0.79 | CDK2 (0.49) | ICMTCDK2MAPTSMN1; SMN2MEN1 | |
| SCHEMBL5210504 | 0.79 | TSHR (0.56) | ICMTMAPTSMN1; SMN2 | |
| SCHEMBL5213599 | 0.78 | ICMT (0.61) | ICMTMAPTCNR2MEN1KMT2A | |
| SCHEMBL5207887 | 0.77 | KDM4E (0.60) | MAPTMEN1KMT2ANQO2ALDH1A1 | |
| SCHEMBL5214070 | 0.74 | PPARG (0.57) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7288564-B2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 2007-10-30 | — | — | US | claimed |
| EP-1343757-B1 | INDOLE DERIVATIVES | GLAXO GROUP LTD (GB) | 2007-02-14 | — | — | EP | disclosed |