Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 3/20 | 0.61 |
| ▸ | F2 | P00734 | 2/20 | 0.46 |
| ▸ | F10 | P00742 | 2/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5207800 | 0.85 | ICMT (0.51) | ICMTKDM4EUSP2LMNACYP1A2 | |
| SCHEMBL5206707 | 0.83 | ICMT (0.53) | ICMTF2F10PRSS1ALDH1A1 | |
| SCHEMBL5207887 | 0.83 | KDM4E (0.60) | KDM4EALDH1A1HSD17B10CYP1A2CYP3A4 | |
| SCHEMBL5210851 | 0.82 | MAPT (0.60) | ALDH1A1HSD17B10LMNACYP1A2CYP3A4 | |
| SCHEMBL5210504 | 0.81 | TSHR (0.56) | ICMTKDM4EMAPTNPSR1 | |
| SCHEMBL5211211 | 0.80 | HTR1D (0.48) | ICMTF2F10PRSS1GAA | |
| SCHEMBL23701762 | 0.80 | ICMT (0.81) | ICMTKDM4EALDH1A1USP2LMNA | |
| SCHEMBL5209045 | 0.79 | CDK2 (0.49) | ICMTKMT2AMEN1MAPTNPSR1 | |
| SCHEMBL23701732 | 0.79 | ICMT (0.79) | ICMTKDM4EALDH1A1USP2LMNA | |
| SCHEMBL5214070 | 0.79 | PPARG (0.57) | KDM4EALDH1A1KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7288564-B2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 2007-10-30 | — | — | US | claimed |
| EP-1343757-B1 | INDOLE DERIVATIVES | GLAXO GROUP LTD (GB) | 2007-02-14 | — | — | EP | disclosed |