Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 5/20 | 0.39 |
| ▸ | F2 | P00734 | 3/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.33 |
| ▸ | NPY2R | P49146 | 1/20 | 0.32 |
| ▸ | KLK1 | P06870 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | F11 | P03951 | 1/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7423644 | 0.95 | ACHE (0.39) | ACHEF2ADRA2CPRSS1PRSS2 | |
| Trifluoroacetic Acid SCHEMBL5216054 | 0.94 | ACHE (0.38) | ACHEF2ADRA2CPRSS1PRSS2 | |
| Trifluoroacetic Acid SCHEMBL6486974 | 0.89 | ACHE (0.38) | ACHEADRA2COPRM1OPRD1F11 | |
| Trifluoroacetic Acid SCHEMBL5212837 | 0.89 | ACHE (0.36) | ACHEADRA2CHDAC11HDAC8HDAC6 | |
| Trifluoroacetic Acid SCHEMBL5213057 | 0.87 | ACHE (0.34) | ACHEF2HDAC11HDAC8HDAC6 | |
| Trifluoroacetic Acid SCHEMBL5212873 | 0.87 | ACHE (0.34) | ACHEF2HDAC11HDAC8HDAC6 | |
| Trifluoroacetic Acid SCHEMBL5210467 | 0.87 | F2 (0.37) | F2ADRA2CPRSS1PRSS2PRSS3 | |
| Trifluoroacetic Acid SCHEMBL7431702 | 0.86 | NAMPT (0.34) | ACHEHDAC11HDAC8HDAC6 | |
| Trifluoroacetic Acid SCHEMBL7428691 | 0.86 | CFD (0.43) | ACHEKDM1AHDAC8HDAC6KLKB1 | |
| Trifluoroacetic Acid SCHEMBL7424902 | 0.85 | ACHE (0.34) | ACHEF2HDAC11HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1240154-B1 | SERINE PROTEASE INHIBITORS | TULARIK LTD (GB) | 2007-02-28 | — | — | EP | disclosed |
| US-7157585-B2 | Serine protease inhibitors | TULARIK LIMITED (GB) | 2007-01-02 | — | — | US | disclosed |
| US-20050215587-A1 | Serine protease inhibitors | LIVELY SARAH E | 2005-09-29 | — | — | US | disclosed |
| US-6916957-B2 | Serine protease inhibitors | TULARIK LIMITED (GB) | 2005-07-12 | — | — | US | disclosed |
| US-20030018059-A1 | Serine protease inhibitors | PROTHERICS MOLECULAR DESIGN LIMITED (GB) | 2003-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050215587-A1 | Serine protease inhibitors | PRSS1, TPSAB1, CMA1 | ACHE 480/4885F2 69/4885ADRA2C 2090/4885 |
| US-20030018059-A1 | Serine protease inhibitors | TPSAB1, PRSS1, SERPINB1 | ACHE 1165/4885F2 122/4885ADRA2C 2451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.