Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 5/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 12/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 12/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5210906 | 0.95 | ACHE (0.39) | ACHEOPRM1OPRD1ADRA2CF2 | |
| Trifluoroacetic Acid SCHEMBL6486974 | 0.94 | ACHE (0.38) | ACHEOPRM1OPRD1OPRK1ADRA2C | |
| Trifluoroacetic Acid SCHEMBL7428691 | 0.90 | CFD (0.43) | ACHEKDM1A | |
| Trifluoroacetic Acid SCHEMBL7422801 | 0.90 | ACHE (0.35) | ACHEOPRM1OPRD1OPRK1ADRA2C | |
| Trifluoroacetic Acid SCHEMBL5216054 | 0.89 | ACHE (0.38) | ACHEOPRM1OPRD1ADRA2CF2 | |
| Trifluoroacetic Acid SCHEMBL7426179 | 0.87 | F2 (0.36) | OPRM1OPRD1OPRK1ADRA2CF2 | |
| Trifluoroacetic Acid SCHEMBL5212837 | 0.84 | ACHE (0.36) | ACHEADRA2C | |
| SCHEMBL7431168 | 0.83 | ACHE (0.38) | ACHEOPRM1OPRD1OPRK1ADRA2C | |
| Trifluoroacetic Acid SCHEMBL8040508 | 0.83 | F2 (0.34) | OPRM1OPRD1OPRK1ADRA2CF2 | |
| Trifluoroacetic Acid SCHEMBL5212873 | 0.82 | ACHE (0.34) | ACHEOPRK1F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192135-A2 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000076970-A2 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2000-12-21 | — | — | WO | disclosed |