Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 2/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11885384 | 0.89 | SLC7A5 (0.47) | SLC7A5ESR1ESR2CES2CES1 | |
| SCHEMBL30421033 | 0.83 | CES2 (0.62) | SLC7A5ESR1ESR2CES2CES1 | |
| SCHEMBL8456234 | 0.83 | CES2 (0.62) | SLC7A5ESR1ESR2CES2CES1 | |
| SCHEMBL110296 | 0.82 | SLC7A5 (0.58) | SLC7A5ESR1ESR2STAT3GABRA1 | |
| SCHEMBL177641 | 0.81 | SMN1; SMN2 (0.55) | ESR1ESR2CES2CES1PARP1 | |
| Water SCHEMBL28897664 | 0.81 | SLC7A5 (0.56) | SLC7A5ESR1ESR2STAT3GABRA1 | |
| SCHEMBL28350987 | 0.81 | SLC7A5 (0.56) | SLC7A5ESR1ESR2STAT3GABRA1 | |
| Hydrogen Peroxide SCHEMBL27146001 | 0.81 | SLC7A5 (0.60) | SLC7A5ESR1ESR2STAT3GABRA1 | |
| SCHEMBL30625924 | 0.81 | KMT2A (0.52) | SLC7A5ESR1ESR2CES2CES1 | |
| SCHEMBL13026720 | 0.80 | SLC7A5 (0.56) | SLC7A5STAT3GABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230322777-A1 | N1-Pyrazolospiroketone Acetyl-CoA Carboxylase Inhibitors | PFIZER INC. (US) | 2023-10-12 | — | — | US | disclosed |
| US-11673890-B2 | N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors | PFIZER INC. (US) | 2023-06-13 | — | — | US | disclosed |
| US-20210047325-A1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2021-02-18 | — | — | US | disclosed |
| US-10822335-B2 | N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors | PFIZER INC. (US) | 2020-11-03 | — | — | US | disclosed |
| US-20190218218-A1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2019-07-18 | — | — | US | disclosed |
| US-10294225-B2 | N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors | PFIZER INC. (US) | 2019-05-21 | — | — | US | disclosed |
| US-20180162858-A1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2018-06-14 | — | — | US | disclosed |
| US-9908883-B2 | N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors | PFIZER INC. (US) | 2018-03-06 | — | — | US | disclosed |
| US-20160347752-A1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2016-12-01 | — | — | US | disclosed |
| EP-2621493-B1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | PFIZER (US) | 2016-08-17 | — | — | EP | disclosed |
| US-20150011470-A1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2015-01-08 | — | — | US | disclosed |
| US-8859577-B2 | N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors | PFIZER INC. (US) | 2014-10-14 | — | — | US | disclosed |
| US-20130190334-A1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2013-07-25 | — | — | US | disclosed |
| US-8471005-B2 | Pyrrolotriazines as ALK and JAK2 inhibitors | CEPHALON, INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20120028919-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2012-02-02 | — | — | US | disclosed |
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| US-20100317621-A1 | BETA-LACTAMASE INHIBITORS | PROTEZ PHARMACEUTICALS, INC. | 2010-12-16 | — | — | US | disclosed |
| EP-2220096-A1 | BETA-LACTAMASE INHIBITORS | Protez Pharmaceuticals, Inc. (US) | 2010-08-25 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |
| WO-2009064413-A1 | BETA-LACTAMASE INHIBITORS | PROTEZ PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130190334-A1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | ACACA, ACACB, PC | SLC7A5 2515/4885ESR1 2828/4885ESR2 2472/4885 |
| US-20230322777-A1 | N1-Pyrazolospiroketone Acetyl-CoA Carboxylase Inhibitors | ACACA, ACACB, PC | SLC7A5 3013/4885ESR1 2983/4885ESR2 2852/4885 |
| US-20100317621-A1 | BETA-LACTAMASE INHIBITORS | GANAB, BPGM, BLVRB | SLC7A5 346/4885ESR1 2915/4885ESR2 2546/4885 |
| US-11673890-B2 | N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors | ACACA, ACACB, PC | SLC7A5 3042/4885ESR1 2974/4885ESR2 2858/4885 |
| US-20190218218-A1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | ACACA, ACACB, PC | SLC7A5 2904/4885ESR1 3022/4885ESR2 2870/4885 |
| US-20160347752-A1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | ACACA, ACACB, PC | SLC7A5 3013/4885ESR1 2983/4885ESR2 2852/4885 |
| US-10294225-B2 | N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors | ACACA, ACACB, PC | SLC7A5 3013/4885ESR1 2983/4885ESR2 2852/4885 |
| US-20210047325-A1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | ACACA, ACACB, PC | SLC7A5 3042/4885ESR1 2974/4885ESR2 2858/4885 |
| US-20150011470-A1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | ACACA, ACACB, PC | SLC7A5 3013/4885ESR1 2983/4885ESR2 2852/4885 |
| US-20120028919-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | JAK2, ALK, ABL1 | SLC7A5 1876/4885ESR1 3401/4885ESR2 3566/4885 |
| US-10822335-B2 | N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors | ACACA, ACACB, PC | SLC7A5 3013/4885ESR1 2983/4885ESR2 2852/4885 |
| US-20180162858-A1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | ACACA, ACACB, PC | SLC7A5 3013/4885ESR1 2983/4885ESR2 2852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.