Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.31 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL567320 | 1.00 | BRD4 (0.41) | BRD4OPRM1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL567321 | 1.00 | BRD4 (0.41) | BRD4OPRM1SLC6A4SLC6A2SLC6A3 | |
| Hydrochloric Acid SCHEMBL7093253 | 0.98 | BRD4 (0.40) | BRD4OPRM1SLC6A4SLC6A2SLC6A3 | |
| Hydrochloric Acid SCHEMBL30427479 | 0.98 | BRD4 (0.40) | BRD4OPRM1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL15760245 | 0.89 | OPRM1 (0.46) | BRD4OPRM1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL630094 | 0.86 | OPRM1 (0.48) | BRD4OPRM1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL1963692 | 0.81 | BRD4 (0.47) | BRD4OPRM1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL2811875 | 0.81 | OPRM1 (0.42) | BRD4OPRM1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL17892425 | 0.80 | NPSR1 (0.37) | OPRM1SMN1; SMN2MEN1KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL25271505 | 0.80 | BRD4 (0.46) | BRD4OPRM1SLC6A4SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115536696-B | ENPP1 inhibitors | 上海齐鲁制药研究中心有限公司 | 2023-07-14 | — | — | CN | disclosed |
| US-20230212122-A1 | MITOCHONDRIAL TARGETING COMPOUNDS FOR THE TREATMENT OF ASSOCIATED DISEASES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-07-06 | — | — | US | disclosed |
| EP-4157263-A1 | MITOCHONDRIAL TARGETING COMPOUNDS FOR THE TREATMENT OF ASSOCIATED DISEASES | The Regents Of The University Of Michigan (US) | 2023-04-05 | — | — | EP | disclosed |
| CN-115536696-A | ENPP1 inhibitors | 上海齐鲁制药研究中心有限公司 | 2022-12-30 | — | — | CN | disclosed |
| EP-1322596-B1 | ZWITTERIONIC TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2007-08-15 | — | — | EP | disclosed |
| US-6906085-B2 | Tetrahydropyran derivatives as neurokinin receptor antagonists | MERCK SHARP & DOHME LTD. | 2005-06-14 | — | — | US | disclosed |
| US-20040063974-A1 | Tetrahydropyran derivatives as neurokinin receptor antagonists | MERCK SHARP & DOHME, LTD. (GB) | 2004-04-01 | — | — | US | disclosed |
| EP-1377565-A1 | TETRAHYDROPYRAN DERIVATIVES AS NEUROKININ RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 2004-01-07 | — | — | EP | disclosed |
| EP-1322596-A1 | ZWITTERIONIC TACHYKININ RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2003-07-02 | — | — | EP | disclosed |
| US-6479518-B2 | PSYCHOLOGICAL DISORDERS | MERCK & CO., INC. | 2002-11-12 | — | — | US | disclosed |
| WO-2002057250-A1 | TETRAHYDROPYRAN DERIVATIVES AS NEUROKININ RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |
| US-20020042431-A1 | Zwitterionic tachykinin receptor antagonists | MERCK & CO., INC. | 2002-04-11 | — | — | US | disclosed |
| WO-2002024629-A1 | ZWITTERIONIC TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2002-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020042431-A1 | Zwitterionic tachykinin receptor antagonists | NPY5R, NPY1R, NPY2R | BRD4 3300/4885OPRM1 163/4885SLC6A4 124/4885 |
| US-20040063974-A1 | Tetrahydropyran derivatives as neurokinin receptor antagonists | NPSR1, OPRK1, CCKAR | BRD4 2935/4885OPRM1 34/4885SLC6A4 660/4885 |
| US-20230212122-A1 | MITOCHONDRIAL TARGETING COMPOUNDS FOR THE TREATMENT OF ASSOCIATED DISEASES | TFAM, CS, FH | BRD4 1909/4885OPRM1 4778/4885SLC6A4 3735/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.