Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | AOC2 | O75106 | 5/20 | 0.42 |
| ▸ | MAOA | P21397 | 5/20 | 0.42 |
| ▸ | MAOB | P27338 | 5/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3568561 | 0.87 | HPGD (0.46) | HPGDTSHRAOC2MAOAMAOB | |
| SCHEMBL1519282 | 0.86 | SMN1; SMN2 (0.51) | HPGDTSHRAOC2MAOAMAOB | |
| SCHEMBL3885950 | 0.84 | HPGD (0.44) | HPGDTSHRAOC2MAOAMAOB | |
| SCHEMBL16296612 | 0.83 | POLB (0.43) | HPGDTSHRAOC2MAOAMAOB | |
| SCHEMBL29974170 | 0.81 | HPGD (0.59) | HPGDTSHRAOC2MAOAMAOB | |
| SCHEMBL860446 | 0.81 | HPGD (0.59) | HPGDTSHRAOC2MAOAMAOB | |
| SCHEMBL1519251 | 0.77 | SIGMAR1 (0.45) | HPGDTSHR | |
| SCHEMBL25798208 | 0.75 | HPGD (0.53) | HPGDTSHRHDAC3HDAC4HDAC1 | |
| SCHEMBL28551393 | 0.75 | LMNA (0.42) | HPGDTSHRAOC2MAOAMAOB | |
| SCHEMBL10664459 | 0.73 | MEN1 (0.36) | HPGDTSHRAOC2MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9850276-B2 | Bidentate-binding modulators of LRRK2 and JNK kinases | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-12-26 | — | — | US | disclosed |
| US-20160185818-A1 | BIDENTATE-BINDING MODULATORS OF LRRK2 AND JNK KINASES | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED | 2016-06-30 | — | — | US | disclosed |
| EP-3003302-A1 | BIDENTATE-BINDING MODULATORS OF LRRK2 AND JNK KINASES | The Scripps Research Institute (US) | 2016-04-13 | — | — | EP | disclosed |
| WO-2014200682-A1 | BIDENTATE-BINDING MODULATORS OF LRRK2 AND JNK KINASES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-12-18 | — | — | WO | disclosed |
| EP-1112270-B1 | DIHYDROBENZODIOXINE CARBOXAMIDE AND KETONE DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2007-03-21 | — | — | EP | disclosed |
| CN-1142161-C | Dihydrobenzodioxine carboxamide and ketone derivatives as 5-HT 4 receptor antagonists | - | 2004-03-17 | — | — | CN | disclosed |
| CN-1315950-A | Dihydrobenzodioxine carboxamide and ketone derivatives as 5-HT 4 receptor antagonists | HOFFMANN LA ROCHE (CH) | 2001-10-03 | — | — | CN | disclosed |
| EP-1112270-A1 | DIHYDROBENZODIOXINE CARBOXAMIDE AND KETONE DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-07-04 | — | — | EP | disclosed |
| US-6172062-B1 | ANTISEROTONIN AGENTS; GASTROINTESTINAL DISORDERS; CARDIOVASCULAR DISORDERS; NERVOUS SYSTEM DISORDERS | SYNTEX (USA) LLC | 2001-01-09 | — | — | US | disclosed |
| US-6172062-B1 | ANTISEROTONIN AGENTS; GASTROINTESTINAL DISORDERS; CARDIOVASCULAR DISORDERS; NERVOUS SYSTEM DISORDERS | SYNTEX (USA) LLC | 2001-01-09 | — | — | US | disclosed |
| US-5602129-A | GASTROINTESTINAL DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-02-11 | — | — | US | disclosed |
| US-5576448-A | GASTROINTESTINAL DISORDERS, ANTIEMETICS, ANTIPSYCHOTICS OR NEUROLEPTIC AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-11-19 | — | — | US | disclosed |
| US-5565582-A | GASTROINTESTINAL DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-10-15 | — | — | US | disclosed |
| US-5554772-A | CHEMICAL INTERMEDIATES; GASTROINTESTINAL DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-09-10 | — | — | US | disclosed |
| US-5552553-A | CHEMICAL INTERMEDIATES FOR LAXATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-09-03 | — | — | US | disclosed |
| US-5536733-A | GASTROINTESTINAL | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-07-16 | — | — | US | disclosed |
| US-5521314-A | CHEMICAL INTERMEDIATES FOR CENTRAL NERVOUS SYSTEM, ANTIEMETICS, ANTIPSYCHOTIC AGENTS OR NEUROLEPTIC AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-05-28 | — | — | US | disclosed |
| EP-0389037-B1 | N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1995-09-20 | — | — | EP | disclosed |
| US-5374637-A | Stimulate gastrointestinal motility | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-12-20 | — | — | US | disclosed |
| EP-0389037-A1 | N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-09-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160185818-A1 | BIDENTATE-BINDING MODULATORS OF LRRK2 AND JNK KINASES | LRRK2, PINK1, MAP2K3 | HPGD 1753/4885TSHR 3523/4885AOC2 4800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.