Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 7/20 | 0.38 |
| ▸ | AOC2 | O75106 | 5/20 | 0.38 |
| ▸ | MAOA | P21397 | 5/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3568561 | 0.86 | HPGD (0.46) | HPGDTSHRNFKB1NFKB2RELA | |
| SCHEMBL5215909 | 0.84 | HPGD (0.45) | HPGDTSHRNFKB1NFKB2RELA | |
| SCHEMBL1519282 | 0.84 | SMN1; SMN2 (0.51) | HPGDTSHRNFKB1NFKB2RELA | |
| SCHEMBL2176045 | 0.82 | HPGD (0.58) | HPGDTSHRNFKB1NFKB2RELA | |
| SCHEMBL16296612 | 0.79 | POLB (0.43) | HPGDTSHRNFKB1NFKB2RELA | |
| SCHEMBL1519251 | 0.75 | SIGMAR1 (0.45) | HPGDTSHR | |
| SCHEMBL28551393 | 0.73 | LMNA (0.42) | HPGDTSHRMAOBAOC2MAOA | |
| SCHEMBL25798208 | 0.73 | HPGD (0.53) | HPGDTSHRHDAC3HDAC4HDAC1 | |
| SCHEMBL10654103 | 0.72 | MAOB (0.39) | HPGDTSHRMAOBAOC2MAOA | |
| SCHEMBL449445 | 0.72 | MAOA (0.37) | HPGDTSHRMAOBAOC2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090042895-A1 | Antidepressant Piperidine Derivatives of Heterocycle-Fused Benzodioxans | WYETH (US) | 2009-02-12 | — | — | US | disclosed |
| US-7488751-B2 | Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan | WYETH (US) | 2009-02-10 | — | — | US | disclosed |
| US-7479500-B2 | Antidepressant piperidine derivatives of heterocyclefused benzodioxans | WYETH (US) | 2009-01-20 | — | — | US | disclosed |
| US-7419986-B2 | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans | WYETH (US) | 2008-09-02 | — | — | US | disclosed |
| US-7335666-B2 | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans | WYETH (US) | 2008-02-26 | — | — | US | disclosed |
| US-20070004702-A1 | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans | WYETH (US) | 2007-01-04 | — | — | US | disclosed |
| US-20060293301-A1 | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans | WYETH (US) | 2006-12-28 | — | — | US | disclosed |
| US-7135479-B2 | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans | WYETH (US) | 2006-11-14 | — | — | US | disclosed |
| US-20060160881-A1 | Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan | WYETH (US) | 2006-07-20 | — | — | US | disclosed |
| US-20060148881-A1 | Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-Benzodioxan | WYETH (US) | 2006-07-06 | — | — | US | disclosed |
| US-20040132714-A1 | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans | WYETH | 2004-07-08 | — | — | US | disclosed |
| US-20040127543-A1 | Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan | WYETH | 2004-07-01 | — | — | US | disclosed |
| WO-2004024733-A1 | ANTIDEPRESSANT PIPERIDINE DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS | WYETH (US) | 2004-03-25 | — | — | WO | disclosed |
| WO-2004024730-A1 | ANTIDEPRESSANT AZAHETEROCYCLYLMETHYL DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS | WYETH (US) | 2004-03-25 | — | — | WO | disclosed |
| WO-2004024723-A1 | ANTIDEPRESSANT CYCLOALKYLAMINE DERIVATIVES OF 2,3-DIHYDRO-1,4-BENZODIOXAN | WYETH (US) | 2004-03-25 | — | — | WO | disclosed |
| EP-1381600-A1 | ANTIDEPRESSANT AZAHETEROCYCLYLMETHYL DERIVATIVES OF 2,3-DIHYDRO-1,4-BENZODIOXAN | Wyeth, A Corporation of the State of Delaware (US) | 2004-01-21 | — | — | EP | disclosed |
| US-20030236241-A1 | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-benzodioxan | WYETH | 2003-12-25 | — | — | US | disclosed |
| US-6559169-B2 | For therapy of depression, anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder attention deficit disorder,obsessive compulsive disorder, obesity, eating disorders, sexual dysfunction | WYETH | 2003-05-06 | — | — | US | disclosed |
| US-20020193400-A1 | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-benzodioxan | WYETH (US) | 2002-12-19 | — | — | US | disclosed |
| WO-2002085896-A1 | ANTIDEPRESSANT AZAHETEROCYCLYLMETHYL DERIVATIVES OF 2,3-DIHYDRO-1,4-BENZODIOXAN | WYETH (US) | 2002-10-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020193400-A1 | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-benzodioxan | OPRD1, DRD1, DRD2 | HPGD 312/4885TSHR 2555/4885NFKB1 1039/4885 |
| US-20060160881-A1 | Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan | HTR5A, OPRD1, DRD2 | HPGD 910/4885TSHR 2515/4885NFKB1 420/4885 |
| US-20060293301-A1 | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans | CRH, HTR5A, DBH | HPGD 928/4885TSHR 1338/4885NFKB1 500/4885 |
| US-20030236241-A1 | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-benzodioxan | OPRD1, DRD1, DRD2 | HPGD 312/4885TSHR 2555/4885NFKB1 1039/4885 |
| US-20040127543-A1 | Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan | HTR5A, OPRD1, TAAR5 | HPGD 1004/4885TSHR 2117/4885NFKB1 501/4885 |
| US-20060148881-A1 | Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-Benzodioxan | HTR5A, OPRD1, DRD2 | HPGD 910/4885TSHR 2515/4885NFKB1 420/4885 |
| US-20070004702-A1 | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans | CRH, CYP19A1, HTR5A | HPGD 927/4885TSHR 1187/4885NFKB1 414/4885 |
| US-20040132714-A1 | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans | CYP19A1, CRH, CYP17A1 | HPGD 1126/4885TSHR 1069/4885NFKB1 434/4885 |
| US-20090042895-A1 | Antidepressant Piperidine Derivatives of Heterocycle-Fused Benzodioxans | HTR5A, OPRD1, CRH | HPGD 839/4885TSHR 1272/4885NFKB1 165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.