Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.32 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5219348 | 0.91 | KDM4E (0.39) | KDM4ELMNACYP3A4GABRA1TSHR | |
| SCHEMBL5212276 | 0.88 | IKBKB (0.32) | HTR4 | |
| SCHEMBL5213847 | 0.88 | ALDH1A1 (0.31) | HTR4 | |
| SCHEMBL5215923 | 0.88 | LMNA (0.38) | HTR4LMNATSHR | |
| SCHEMBL5215599 | 0.86 | KDM4E (0.34) | KDM4EKMT2AHTR4 | |
| SCHEMBL5213651 | 0.85 | ALDH1A1 (0.37) | KDM4EKMT2AHTR4 | |
| SCHEMBL5215519 | 0.85 | HTR4 (0.33) | HTR4LMNA | |
| SCHEMBL5216323 | 0.85 | NPC1 (0.32) | — | |
| SCHEMBL5212565 | 0.84 | ADH1B (0.32) | — | |
| SCHEMBL5218969 | 0.84 | HTR4 (0.35) | KDM4EKMT2AHTR4LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1112270-B1 | DIHYDROBENZODIOXINE CARBOXAMIDE AND KETONE DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2007-03-21 | — | — | EP | disclosed |