Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.30 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.30 |
| ▸ | F2R | P25116 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5213847 | 0.85 | ALDH1A1 (0.31) | ALDH1A1HTR4 | |
| SCHEMBL5219348 | 0.85 | KDM4E (0.39) | KDM4EITGB3ITGA2BF2R | |
| SCHEMBL5216238 | 0.85 | KDM4E (0.33) | KDM4EKMT2AHTR4 | |
| SCHEMBL5212276 | 0.83 | IKBKB (0.32) | HTR4 | |
| SCHEMBL5215599 | 0.81 | KDM4E (0.34) | ALDH1A1KDM4EKMT2AHTR4 | |
| SCHEMBL5215923 | 0.80 | LMNA (0.38) | ALDH1A1HTR4 | |
| SCHEMBL5215519 | 0.80 | HTR4 (0.33) | HTR4GAA | |
| SCHEMBL7446739 | 0.79 | ITGB3 (0.40) | ALDH1A1KDM4EHRH3MEN1KMT2A | |
| SCHEMBL5219473 | 0.79 | GNAO1 (0.38) | ALDH1A1KDM4EMEN1KMT2AALOX15 | |
| SCHEMBL5218969 | 0.79 | HTR4 (0.35) | ALDH1A1KDM4EMEN1KMT2AHTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1112270-B1 | DIHYDROBENZODIOXINE CARBOXAMIDE AND KETONE DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2007-03-21 | — | — | EP | claimed |
| EP-1112270-B1 | DIHYDROBENZODIOXINE CARBOXAMIDE AND KETONE DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2007-03-21 | — | — | EP | disclosed |