Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 15/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5422892 | 0.85 | PYGL (0.49) | PYGLMMP1MMP2MMP3MMP7 | |
| SCHEMBL5195746 | 0.74 | RAB9A (0.40) | PYGLCYP2C9L3MBTL1RAB9A | |
| SCHEMBL5194761 | 0.74 | PYGL (0.39) | PYGLMMP1MMP2MMP3MMP7 | |
| SCHEMBL5193828 | 0.73 | PYGL (0.60) | PYGLCYP2C9IDO1 | |
| SCHEMBL5191881 | 0.73 | MMP1 (0.42) | MMP1MMP2MMP3MMP7MMP13 | |
| SCHEMBL5192366 | 0.73 | KDM4E (0.48) | PYGLMMP13RAB9AKMT2AAAK1 | |
| SCHEMBL5191876 | 0.72 | PYGL (0.62) | PYGLCYP2C9IDO1 | |
| SCHEMBL5192203 | 0.72 | MMP13 (0.46) | MMP1MMP2MMP3MMP7MMP13 | |
| SCHEMBL5195809 | 0.71 | PYGL (0.50) | PYGLCYP2C9IDO1 | |
| Hydrochloric Acid SCHEMBL5192284 | 0.71 | PYGL (0.61) | PYGLCYP2C9IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812383-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | Smithkline Beecham Corporation (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006052722-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-18 | — | — | WO | disclosed |