Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.41 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3717417 | 0.83 | ADRB2 (0.58) | HSD11B1ALDH1A1ADRB2HTTHPGD | |
| SCHEMBL3618445 | 0.79 | ADRB2 (0.65) | ALDH1A1ADRB2HTTEPHX2KMT2A | |
| SCHEMBL5220049 | 0.78 | L3MBTL1 (0.49) | HSD11B1ALDH1A1EPHX2CTBP2KMT2A | |
| SCHEMBL5913507 | 0.77 | MAOA (0.42) | HSD11B1ALDH1A1ADRB2HTT | |
| SCHEMBL21826102 | 0.75 | L3MBTL1 (0.49) | HSD11B1ALDH1A1EPHX2CTBP2KMT2A | |
| SCHEMBL30601825 | 0.74 | HSD11B1 (0.51) | HSD11B1ALDH1A1EPHX2CTBP2KMT2A | |
| SCHEMBL26123313 | 0.74 | HSD11B1 (0.51) | HSD11B1ALDH1A1EPHX2CTBP2KMT2A | |
| SCHEMBL12821484 | 0.73 | ADRB2 (0.58) | ALDH1A1ADRB2HTTEPHX2HPGD | |
| SCHEMBL25518220 | 0.73 | PNMT (0.46) | HSD11B1EPHX2KMT2AMEN1TAAR1 | |
| SCHEMBL20482850 | 0.72 | ALDH1A1 (0.51) | ALDH1A1EPHX2KMT2AMEN1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |
| EP-1567488-A1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LIMITED (GB) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004050619-A1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LIMITED (GB) | 2004-06-17 | — | — | WO | disclosed |