Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | DRD2 | P14416 | 4/20 | 0.38 |
| ▸ | DRD4 | P21917 | 4/20 | 0.38 |
| ▸ | DRD3 | P35462 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5227160 | 0.92 | SMO (0.41) | SMOMAPTDRD2DRD4DRD3 | |
| SCHEMBL5224829 | 0.89 | SMO (0.42) | SMOMAPTDRD2DRD4DRD3 | |
| SCHEMBL5224226 | 0.82 | L3MBTL1 (0.36) | SMOMAPTDRD2DRD4DRD3 | |
| SCHEMBL5224144 | 0.80 | HTR2C (0.38) | SMOMAPT | |
| SCHEMBL5225265 | 0.79 | SMO (0.59) | SMOMAPTDRD2DRD4DRD3 | |
| SCHEMBL5228311 | 0.78 | NR3C1 (0.34) | SMOLMNANPC1HPGDTSHR | |
| SCHEMBL5222796 | 0.78 | NR3C1 (0.35) | SMOLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5228124 | 0.76 | SMO (0.43) | SMOMAPTDRD2DRD4DRD3 | |
| SCHEMBL2761009 | 0.75 | SMO (0.43) | SMOMAPTDRD2DRD4DRD3 | |
| SCHEMBL2761237 | 0.75 | SMO (0.43) | SMOMAPTDRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611122-B1 | SUBSTITUTED PYRAZOLE COMPOUNDS | MERCK PATENT GMBH (DE) | 2007-06-13 | — | — | EP | disclosed |