Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSG | P08311 | 1/20 | 0.48 |
| ▸ | CMA1 | P23946 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 6/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.39 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5223861 | 1.00 | CTSG (0.48) | CTSGCMA1KDM4EALDH1A1TAAR1 | |
| SCHEMBL5226954 | 0.92 | OPRM1 (0.47) | KDM4EALDH1A1TAAR1BCHEBACE1 | |
| SCHEMBL5226961 | 0.92 | OPRM1 (0.47) | KDM4EALDH1A1TAAR1BCHEBACE1 | |
| SCHEMBL5223889 | 0.83 | ALDH1A1 (0.38) | ALDH1A1BCHEBACE1OPRM1OPRD1 | |
| SCHEMBL5223892 | 0.83 | ALDH1A1 (0.38) | ALDH1A1BCHEBACE1OPRM1OPRD1 | |
| SCHEMBL5219646 | 0.83 | ADRB3 (0.43) | KDM4EBCHEBACE1OPRM1OPRD1 | |
| SCHEMBL5219638 | 0.83 | ADRB3 (0.43) | KDM4EBCHEBACE1OPRM1OPRD1 | |
| SCHEMBL5217626 | 0.83 | SIGMAR1 (0.43) | OPRM1KMT2A | |
| SCHEMBL5217634 | 0.83 | SIGMAR1 (0.43) | OPRM1KMT2A | |
| SCHEMBL5216394 | 0.82 | OPRM1 (0.47) | KDM4EALDH1A1BCHEBACE1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |