Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | CASR | P41180 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5217634 | 1.00 | SIGMAR1 (0.43) | SIGMAR1KMT2AMTNR1AMETAP2HRH4 | |
| SCHEMBL5223889 | 0.87 | ALDH1A1 (0.38) | KMT2AOPRM1 | |
| SCHEMBL5223892 | 0.87 | ALDH1A1 (0.38) | KMT2AOPRM1 | |
| SCHEMBL5219638 | 0.86 | ADRB3 (0.43) | KMT2AOPRM1 | |
| SCHEMBL5219646 | 0.86 | ADRB3 (0.43) | KMT2AOPRM1 | |
| SCHEMBL5226954 | 0.84 | OPRM1 (0.47) | KMT2AMTNR1AOPRM1 | |
| SCHEMBL5226961 | 0.84 | OPRM1 (0.47) | KMT2AMTNR1AOPRM1 | |
| SCHEMBL5223850 | 0.83 | CTSG (0.48) | KMT2AOPRM1 | |
| SCHEMBL5223861 | 0.83 | CTSG (0.48) | KMT2AOPRM1 | |
| SCHEMBL5224496 | 0.81 | ADRB3 (0.42) | KMT2AOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |