Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.37 |
| ▸ | CHKA | P35790 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5225922 | 0.89 | L3MBTL1 (0.53) | SMOLMNAMAPTL3MBTL1KMT2A | |
| SCHEMBL5225265 | 0.79 | SMO (0.59) | SMOLMNAMAPTL3MBTL1KMT2A | |
| SCHEMBL5226797 | 0.79 | SMO (0.61) | SMOLMNAMAPTL3MBTL1KMT2A | |
| SCHEMBL5229662 | 0.79 | SMO (0.58) | SMOLMNAMAPTL3MBTL1KMT2A | |
| SCHEMBL5228124 | 0.77 | SMO (0.43) | SMOLMNAMAPTL3MBTL1 | |
| SCHEMBL2761123 | 0.77 | SMO (0.50) | SMOLMNAMAPTL3MBTL1KMT2A | |
| SCHEMBL5224829 | 0.74 | SMO (0.42) | SMOLMNAMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL5226795 | 0.73 | SMO (0.42) | SMOLMNAMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL5223490 | 0.73 | SMO (0.40) | SMOLMNAMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL5227160 | 0.72 | SMO (0.41) | SMOLMNAMAPTL3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611122-B1 | SUBSTITUTED PYRAZOLE COMPOUNDS | MERCK PATENT GMBH (DE) | 2007-06-13 | — | — | EP | disclosed |