SCHEMBL522436

SCHEMBL522436

OCc1ccc(CO)c(Cl)c1Cl

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APOBEC3G Q9HC16 1/20 0.36
PDXK O00764 1/20 0.34
PDK2 Q15119 1/20 0.32
MAPT P10636 1/20 0.32
NPC1 O15118 2/20 0.32
RAB9A P51151 2/20 0.32
KDM4E B2RXH2 2/20 0.32
LMNA P02545 1/20 0.32
GAA P10253 1/20 0.32
HTT P42858 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
RECQL P46063 1/20 0.32
CYP2A6 P11509 1/20 0.32
TSHR P16473 1/20 0.32
PSEN1 P49768 1/20 0.31
PSEN2 P49810 1/20 0.31
APH1B Q8WW43 1/20 0.31
NCSTN Q92542 1/20 0.31
APH1A Q96BI3 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2090168 0.89 CYP3A4 (0.46) APOBEC3GCYP2A6TSHRPNMT
SCHEMBL17069845 0.84 ALDH1A1 (0.35) MAPTNPC1RAB9ASMN1; SMN2L3MBTL1
SCHEMBL2361510 0.84 ALDH1A1 (0.35) LMNAPSEN1PSEN2APH1BNCSTN
SCHEMBL19942221 0.84 PTGER4 (0.33)
SCHEMBL17069835 0.84 NOTUM (0.34) MAPTNOTUM
SCHEMBL16960713 0.81 PNMT (0.44) APOBEC3GPDK2MAPTKDM4ELMNA
SCHEMBL543047 0.79 TSHR (0.45) MAPTKDM4EHTTSMN1; SMN2TSHR
SCHEMBL5747160 0.79 TDP1 (0.38) NPC1RAB9AKDM4ELMNAHTT
SCHEMBL2361509 0.79 PDCD1 (0.36) LMNACYP2A6PSEN1PSEN2APH1B
SCHEMBL24823683 0.77 CYP2A6 (0.41) KDM4ECYP2A6TSHRPNMTNOTUM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100297374-A1 In Situ Moisture Generation and Use of Polyfunctional Alcohols for Crosslinking of Silane-Functionalized Resins DOW GLOBAL TECHNOLOGIES INC. (US) 2010-11-25 US claimed
EP-2207851-A2 IN SITU MOISTURE GENERATION AND USE OF POLYFUNCTIONAL ALCOHOLS FOR CROSSLINKING OF SILANE-FUNCTIONALIZED RESINS Dow Global Technologies Inc. (US) 2010-07-21 EP claimed
WO-2009058545-A2 IN SITU MOISTURE GENERATION AND USE OF POLYFUNCTIONAL ALCOHOLS FOR CROSSLINKING OF SILANE-FUNCTIONALIZED RESINS DOW GLOBAL TECHNOLOGIES INC. (US) 2009-05-07 WO claimed
EP-2415741-A1 METHOD FOR PRODUCING ALCOHOL COMPOUND Sumitomo Chemical Company, Limited (JP) 2012-02-08 EP disclosed
EP-2415742-A1 METHOD FOR PRODUCING ALCOHOL COMPOUND AND CATALYST THEREFOR Sumitomo Chemical Company, Limited (JP) 2012-02-08 EP disclosed
US-20120029195-A1 METHOD FOR PRODUCING ALCOHOL COMPOUND AND CATALYST THEREFOR SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-02-02 US disclosed
US-20120010417-A1 METHOD FOR PRODUCING ALCOHOL COMPOUND SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-01-12 US disclosed
EP-1978008-B1 METHOD FOR PRODUCING HALOGEN-SUBSTITUTED BENZENEDIMETHANOL SUMITOMO CHEMICAL CO (JP) 2011-07-20 EP disclosed
US-7973201-B2 Process for production of halogen-substituted benzenedimethanol SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-07-05 US disclosed
US-7956223-B2 Method for producing halogen-substituted benzenedimethanol SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-06-07 US disclosed
EP-1783108-B1 METHOD FOR PRODUCING HALOGEN-SUBSTITUTED BENZENEDIMETHANOL SUMITOMO CHEMICAL CO (JP) 2010-12-22 EP disclosed
US-7678947-B2 reacting a halogen-substituted terephthalic acid diester with a borohydride compound in the presence of an alcohol and a solvent SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-03-16 US disclosed
EP-2033944-A1 PROCESS FOR PRODUCTION OF HALOGEN-SUBSTITUTED BENZENEDIMETHANOL Sumitomo Chemical Company, Limited (JP) 2009-03-11 EP disclosed
EP-1978008-A1 METHOD FOR PRODUCING HALOGEN-SUBSTITUTED BENZENEDIMETHANOL Sumitomo Chemical Company, Limited (JP) 2008-10-08 EP disclosed
US-20070213570-A1 reacting a halogen-substituted terephthalic acid diester with a borohydride compound in the presence of an alcohol and a solvent SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-09-13 US disclosed
EP-1783108-A1 METHOD FOR PRODUCING HALOGEN-SUBSTITUTED BENZENEDIMETHANOL Sumitomo Chemical Company, Limited (JP) 2007-05-09 EP disclosed
US-5069970-A Polyester and polyolefin, melt spinnable ALLIED-SIGNAL INC. (US) 1991-12-03 US disclosed
US-4908052-A Body comprising network of fibers; for removal of entrained solid particles from fluid stream ALLIED-SIGNAL INC. (US) 1990-03-13 US disclosed
EP-0356424-A1 FILTER ELEMENTS USING IMPROVED SYNTHETIC FIBERS AlliedSignal Inc. (US) 1990-03-07 EP disclosed
WO-1988008463-A1 IMPROVED FIBERS AND FILTERS CONTAINING SAID FIBERS ALLIED CORPORATION (US) 1988-11-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010417-A1 METHOD FOR PRODUCING ALCOHOL COMPOUND ADH1A, ADH1C, ADH5 APOBEC3G 1978/4885PDXK 2192/4885PDK2 254/4885
US-20070213570-A1 reacting a halogen-substituted terephthalic acid diester with a borohydride compound in the presence of an alcohol and a solvent ADH1A, ADH1C, CYP4A11 APOBEC3G 2145/4885PDXK 2706/4885PDK2 1706/4885
US-20120029195-A1 METHOD FOR PRODUCING ALCOHOL COMPOUND AND CATALYST THEREFOR ADH1A, ADH1C, ADH5 APOBEC3G 1935/4885PDXK 1639/4885PDK2 76/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.