Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3365792 | 0.89 | HTT (0.57) | HTTTRPA1LMNAL3MBTL1P2RX7 | |
| SCHEMBL27564141 | 0.81 | HTT (0.56) | HTTTRPA1LMNAMAPK1L3MBTL1 | |
| SCHEMBL8185351 | 0.78 | HTT (0.65) | HTTTRPA1LMNAMAPK1L3MBTL1 | |
| SCHEMBL11510985 | 0.75 | TAS1R3 (0.57) | HTTTRPA1LMNAMAPK1ALDH1A1 | |
| SCHEMBL4652134 | 0.75 | HTT (0.61) | HTTTRPA1LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL1049530 | 0.75 | MAPT (0.48) | LMNAALDH1A1MAPTPOLBTAS1R3 | |
| SCHEMBL12377256 | 0.74 | HTT (0.59) | HTTTRPA1LMNAL3MBTL1P2RX7 | |
| SCHEMBL5222854 | 0.73 | KMT2A (0.52) | HTTLMNAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL10617245 | 0.73 | HTT (0.62) | HTTTRPA1LMNAL3MBTL1P2RX7 | |
| SCHEMBL5194062 | 0.73 | HTT (0.58) | HTTTRPA1LMNAL3MBTL1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740549-A2 | NOVEL IMIDAZOLES | Warner-Lambert Company LLC (US) | 2007-01-10 | — | — | EP | disclosed |
| US-20060287378-A1 | Novel pyrroles and imidazoles | WARNER-LAMBERT COMPANY LLC | 2006-12-21 | — | — | US | disclosed |
| WO-2005105079-A2 | NOVEL IMIDAZOLES | WARNER-LAMBERT COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |
| US-20050239857-A1 | Novel imidazoles | BOLTON GARY L | 2005-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060287378-A1 | Novel pyrroles and imidazoles | PPIP5K2, PPIE, PPOX | HTT 705/4885TRPA1 4192/4885LMNA 4658/4885 |
| US-20050239857-A1 | Novel imidazoles | HMGCR, HMGB2, HMGB3 | HTT 2292/4885TRPA1 4853/4885LMNA 1034/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.