Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 4/20 | 0.43 |
| ▸ | DRD3 | P35462 | 4/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | SMO | Q99835 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.38 |
| ▸ | ALPI | P09923 | 1/20 | 0.36 |
| ▸ | ALPG | P10696 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.36 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5230607 | 0.87 | DRD4 (0.46) | DRD4DRD3DRD2SMOTP53 | |
| SCHEMBL5227774 | 0.86 | DRD3 (0.45) | DRD4DRD3DRD2SMOTP53 | |
| SCHEMBL5230174 | 0.86 | DRD4 (0.46) | DRD4DRD3DRD2SMOTP53 | |
| SCHEMBL5227445 | 0.86 | DRD4 (0.46) | DRD4DRD3DRD2SMOMAPT | |
| SCHEMBL5228024 | 0.83 | HTR2C (0.42) | DRD4DRD3DRD2SMOTP53 | |
| SCHEMBL5229642 | 0.81 | DRD2 (0.42) | DRD4DRD3DRD2SMOTP53 | |
| SCHEMBL2761177 | 0.81 | DRD4 (0.42) | DRD4DRD3DRD2SMOTSHR | |
| SCHEMBL5225751 | 0.80 | SMO (0.54) | SMOMAPTALDH1A1L3MBTL1 | |
| SCHEMBL5226986 | 0.79 | DRD4 (0.39) | DRD4DRD3SMOTP53MAPT | |
| SCHEMBL5224226 | 0.74 | L3MBTL1 (0.36) | DRD4DRD3DRD2SMOTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611122-B1 | SUBSTITUTED PYRAZOLE COMPOUNDS | MERCK PATENT GMBH (DE) | 2007-06-13 | — | — | EP | disclosed |