Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | HTR3A | P46098 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR5A | P47898 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5230180 | 0.90 | HTR1A (0.42) | HRH3HTR1AHTR2AHTR7HTR2B | |
| SCHEMBL5230614 | 0.90 | ACHE (0.51) | HRH3HTR1AHTR2AHTR7HTR2B | |
| SCHEMBL5227779 | 0.89 | ACHE (0.52) | HRH3HTR1AHTR2AHTR7HTR2B | |
| SCHEMBL5229632 | 0.85 | HTR2A (0.40) | HTR1AHTR2AHTR7HTR2BHTR3A | |
| SCHEMBL5226913 | 0.84 | HRH3 (0.45) | HRH3HTR1AHTR2AHTR7HTR2B | |
| SCHEMBL5228031 | 0.81 | MAPK1 (0.40) | HTR1AHTR2AHTR7HTR2BHTR3A | |
| SCHEMBL2761238 | 0.80 | LMNA (0.51) | HRH3HTR1AHTR2AHTR2BHTR2C | |
| SCHEMBL1998316 | 0.80 | HRH3 (0.45) | HRH3HTR1AHTR2AHTR2BHTR2C | |
| Hydrochloric Acid SCHEMBL1997591 | 0.79 | LMNA (0.50) | HRH3GAAMCL1MAPTALDH1A1 | |
| SCHEMBL5223627 | 0.77 | GPR55 (0.42) | HRH3MAPK1GAAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611122-B1 | SUBSTITUTED PYRAZOLE COMPOUNDS | MERCK PATENT GMBH (DE) | 2007-06-13 | — | — | EP | disclosed |